SCHEMBL17828356

SCHEMBL17828356

Cc1cnc(CC(C)(C)C)s1

nearest known ligand 0.44

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
NOS1 P29475 1/20 0.43
SLC6A3 Q01959 1/20 0.40
TRPM5 Q9NZQ8 1/20 0.36
RAB9A P51151 2/20 0.35
SMN1; SMN2 Q16637 2/20 0.33
NPC1 O15118 1/20 0.33
GAA P10253 1/20 0.33
ALDH1A1 P00352 3/20 0.32
GRIN1 Q05586 2/20 0.31
GRIN2B Q13224 2/20 0.31
KDR P35968 1/20 0.31
FDPS P14324 1/20 0.31
HPGD P15428 1/20 0.30
HSD17B10 Q99714 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19386710 0.87 NOS1 (0.45) NOS1SLC6A3TRPM5RAB9ASMN1; SMN2
SCHEMBL24027177 0.84 NOS1 (0.38) NOS1SLC6A3TRPM5RAB9A
SCHEMBL6703014 0.82 NOS1 (0.41) NOS1SLC6A3TRPM5RAB9A
SCHEMBL24297619 0.82 NOS1 (0.36) NOS1SLC6A3TRPM5RAB9AALDH1A1
SCHEMBL13142433 0.78 NOS1 (0.48) NOS1SLC6A3TRPM5RAB9ASMN1; SMN2
SCHEMBL21325317 0.77 RAB9A (0.32) RAB9ANPC1ALDH1A1HPGDHSD17B10
SCHEMBL14298745 0.77 NOS1 (0.35) NOS1SLC6A3TRPM5RAB9A
SCHEMBL127877 0.76
SCHEMBL9917320 0.76 TRPM5 (0.39) TRPM5
SCHEMBL11922139 0.76 LOXL2 (0.31) ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240218004-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2024-07-04 US disclosed
EP-4329463-A2 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES Universal Display Corporation (US) 2024-02-28 EP disclosed
EP-4001287-B1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORP (US) 2024-01-17 EP disclosed
US-20230337520-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2023-10-19 US disclosed
US-20230337520-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2023-10-19 US disclosed
US-20230212207-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2023-07-06 US disclosed
US-20230212139-A1 2-AZASPIRO[3.4]OCTANE DERIVATIVES AS M4 AGONISTS NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, INC. 2023-07-06 US disclosed
US-20230151039-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2023-05-18 US disclosed
US-20230151039-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2023-05-18 US disclosed
US-20230146148-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2023-05-11 US disclosed
US-20230128198-A1 NOVEL HETEROCYCLIC COMPOUNDS USEFUL AS AURORA A SELECTIVE INHIBITORS JACOBIO PHARMACEUTICALS CO., LTD (CN) 2023-04-27 US disclosed
US-20230124696-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2023-04-20 US disclosed
US-20230045960-A1 SUBSTITUTED HETEROAROMATIC PYRAZOLO-PYRIDINES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2023-02-16 US disclosed
US-11530210-B2 Substituted heteroaromatic pyrazolo-pyridines and their use as GLUN2B receptor modulators JANSSEN PHARMACEUTICA NV (BE) 2022-12-20 US disclosed
US-20220165967-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2022-05-26 US disclosed
EP-4001287-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES Universal Display Corporation (US) 2022-05-25 EP disclosed
US-20220077409-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2022-03-10 US disclosed
US-20210017169-A1 SUBSTITUTED HETEROAROMATIC PYRAZOLO-PYRIDINES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2021-01-21 US disclosed
US-10781216-B2 Pyrrolo [3,2-d]pyrimidine derivatives for the treatment of viral infections and other diseases Janssen Sciences Ireland Unlimited Company (IE) 2020-09-22 US disclosed
US-20160168150-A1 PYRROLO[3,2-D]PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS AND OTHER DISEASES JANSSEN SCIENCES IRELAND UC (IE) 2016-06-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (15 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230045960-A1 SUBSTITUTED HETEROAROMATIC PYRAZOLO-PYRIDINES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS GRIN2B, GRIN2A, GRIN2C NOS1 3932/4885SLC6A3 1876/4885TRPM5 1038/4885
US-20230146148-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES OCIAD1, OCIAD2, ICOSLG NOS1 925/4885SLC6A3 3118/4885TRPM5 88/4885
US-20210017169-A1 SUBSTITUTED HETEROAROMATIC PYRAZOLO-PYRIDINES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS GRIN2B, GRIN2A, GRIN2C NOS1 3932/4885SLC6A3 1876/4885TRPM5 1038/4885
US-20230212207-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES OCIAD2, OTC, OCIAD1 NOS1 1282/4885SLC6A3 2895/4885TRPM5 285/4885
US-20160168150-A1 PYRROLO[3,2-D]PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS AND OTHER DISEASES TYMS, TYMP, DPYD NOS1 4365/4885SLC6A3 3585/4885TRPM5 4334/4885
US-20230124696-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES OCIAD1, OCIAD2, CCND1 NOS1 852/4885SLC6A3 3628/4885TRPM5 1100/4885
US-20230337520-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES LBR, LPO, LPL NOS1 2487/4885SLC6A3 3586/4885TRPM5 561/4885
US-20230128198-A1 NOVEL HETEROCYCLIC COMPOUNDS USEFUL AS AURORA A SELECTIVE INHIBITORS AURKA, AURKC, AURKB NOS1 4219/4885SLC6A3 4590/4885TRPM5 3796/4885
US-11530210-B2 Substituted heteroaromatic pyrazolo-pyridines and their use as GLUN2B receptor modulators GRIN2B, GRIN2A, GRIN2C NOS1 3932/4885SLC6A3 1876/4885TRPM5 1038/4885
US-20230212139-A1 2-AZASPIRO[3.4]OCTANE DERIVATIVES AS M4 AGONISTS CHRM2, CHRM1, CHRM3 NOS1 581/4885SLC6A3 899/4885TRPM5 142/4885
US-20220165967-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES OCIAD2, OCIAD1, ICOSLG NOS1 1713/4885SLC6A3 3758/4885TRPM5 80/4885
US-20220077409-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES OCIAD2, ODC1, OTC NOS1 1503/4885SLC6A3 2859/4885TRPM5 246/4885
US-10781216-B2 Pyrrolo [3,2-d]pyrimidine derivatives for the treatment of viral infections and other diseases TYMS, TYMP, DPYD NOS1 4365/4885SLC6A3 3585/4885TRPM5 4334/4885
US-20230151039-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES RPS4X, SOD1, CNKSR1 NOS1 1853/4885SLC6A3 4250/4885TRPM5 1109/4885
US-20240218004-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES OCIAD1, OCIAD2, CCND2 NOS1 1044/4885SLC6A3 4573/4885TRPM5 631/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.