Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 3/20 | 0.37 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.37 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.37 |
| ▸ | MC4R | P32245 | 2/20 | 0.36 |
| ▸ | MC3R | P41968 | 2/20 | 0.36 |
| ▸ | MC1R | Q01726 | 2/20 | 0.36 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 6/20 | 0.33 |
| ▸ | CA2 | P00918 | 6/20 | 0.33 |
| ▸ | CA4 | P22748 | 6/20 | 0.33 |
| ▸ | CA9 | Q16790 | 6/20 | 0.33 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5104471 | 0.79 | ABCB1 (0.43) | ABCB1ABHD6DAGLAMC4RMC3R | |
| SCHEMBL28474415 | 0.75 | ABCB1 (0.42) | ABCB1ABHD6DAGLAMC4RMC3R | |
| SCHEMBL18862950 | 0.72 | HSD11B1 (0.48) | ABCB1ABHD6DAGLAMC4RMC3R | |
| SCHEMBL18862951 | 0.72 | HSD11B1 (0.48) | ABCB1ABHD6DAGLAMC4RMC3R | |
| SCHEMBL14646637 | 0.72 | DPP4 (0.57) | DPP4AGTR2 | |
| SCHEMBL14645771 | 0.72 | DPP4 (0.57) | DPP4AGTR2 | |
| SCHEMBL2801721 | 0.70 | AVPR1A (0.39) | ABCB1ABHD6DAGLAMC4RMC3R | |
| SCHEMBL23459127 | 0.69 | SCD5 (0.57) | ABHD6DAGLAMC4RMC3RMC1R | |
| SCHEMBL908981 | 0.69 | SCD5 (0.57) | ABHD6DAGLAMC4RMC3RMC1R | |
| SCHEMBL23458987 | 0.69 | ALDH1A1 (0.42) | ABCB1TMEM97SIGMAR1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110124671-A1 | SPIROINDENES AND SPIROINDANES AS MODULATORS OF CHEMOKINE RECEPTORS | GLAXO GROUP LIMITED (GB) | 2011-05-26 | — | — | US | disclosed |
| EP-2190286-A1 | SPIROINDENES AND SPIROINDANES AS MODULATORS OF CHEMOKINE RECEPTORS | Glaxo Group Limited (GB) | 2010-06-02 | — | — | EP | disclosed |
| WO-2009023754-A1 | SPIROINDENES AND SPIROINDANES AS MODULATORS OF CHEMOKINE RECEPTORS | GLAXO GROUP LIMITED (GB) | 2009-02-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110124671-A1 | SPIROINDENES AND SPIROINDANES AS MODULATORS OF CHEMOKINE RECEPTORS | CCR2, CXCR2, CCR5 | ABCB1 576/4885ABHD6 3759/4885DAGLA 4313/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.