Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | FABP3 | P05413 | 1/20 | 0.48 |
| ▸ | FABP4 | P15090 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | SMOX | Q9NWM0 | 2/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17850362 | 0.89 | P2RX7 (0.39) | LMNAKMT2APOLBHTTATM | |
| SCHEMBL17850367 | 0.83 | P2RX7 (0.45) | LMNAATM | |
| SCHEMBL17850365 | 0.80 | ATM (0.46) | ALDH1A1MAPTKMT2AGAAPOLB | |
| SCHEMBL17850355 | 0.79 | ATM (0.45) | ALDH1A1MAPTKMT2AGAAPOLB | |
| SCHEMBL17850366 | 0.79 | ATM (0.45) | ALDH1A1MAPTKMT2AGAAATM | |
| SCHEMBL17850360 | 0.75 | P2RX7 (0.43) | ATM | |
| SCHEMBL12852339 | 0.74 | LMNA (0.58) | LMNAALDH1A1MAPTKMT2AFABP3 | |
| SCHEMBL6354490 | 0.74 | LMNA (0.74) | LMNAALDH1A1MAPTKMT2AFABP3 | |
| SCHEMBL6361630 | 0.68 | LMNA (0.68) | LMNAALDH1A1MAPTKMT2AFABP3 | |
| SCHEMBL4979809 | 0.67 | LMNA (0.56) | LMNAALDH1A1MAPTKMT2AFABP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3034494-A1 | HETEROCYCLIC INHIBITORS OF NECROPTOSIS | President and Fellows of Harvard College (US) | 2016-06-22 | — | — | EP | disclosed |