Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 11/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17850367 | 0.93 | P2RX7 (0.45) | P2RX7LMNAATMMAPK1 | |
| SCHEMBL17850365 | 0.90 | ATM (0.46) | P2RX7KMT2AATMPOLBCYP1A2 | |
| SCHEMBL17850366 | 0.89 | ATM (0.45) | P2RX7KMT2AATM | |
| SCHEMBL17850355 | 0.89 | ATM (0.45) | P2RX7KMT2AATMPOLBCYP1A2 | |
| SCHEMBL17850358 | 0.89 | LMNA (0.58) | KMT2ALMNAHTTNPSR1ATM | |
| SCHEMBL17850360 | 0.84 | P2RX7 (0.43) | P2RX7ATM | |
| SCHEMBL17850357 | 0.73 | ATM (0.56) | P2RX7LMNAATMPOLB | |
| SCHEMBL12852318 | 0.68 | ATM (0.58) | P2RX7KMT2ALMNAHTTATM | |
| SCHEMBL17850363 | 0.65 | MAPK14 (0.44) | P2RX7KMT2AATM | |
| SCHEMBL13938748 | 0.65 | SLC6A3 (0.35) | LMNASLC6A3MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3034494-A1 | HETEROCYCLIC INHIBITORS OF NECROPTOSIS | President and Fellows of Harvard College (US) | 2016-06-22 | — | — | EP | disclosed |