SCHEMBL1786525

SCHEMBL1786525

O=C(O)C1(C(F)(F)F)CCCC1

nearest known ligand 0.43

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
DGAT1 O75907 1/20 0.43
CYP2C19 P33261 1/20 0.34
RIPK1 Q13546 2/20 0.34
AKR1C1 Q04828 1/20 0.32
FFAR3 O14843 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL696271 0.97 DGAT1 (0.41) DGAT1CYP2C19RIPK1AKR1C1FFAR3
Hydrochloric Acid SCHEMBL12479454 0.95 DGAT1 (0.40) DGAT1CYP2C19RIPK1AKR1C1
SCHEMBL17586 0.95 DGAT1 (0.43) DGAT1CYP2C19RIPK1FFAR3
SCHEMBL18559 0.89 DGAT1 (0.52) DGAT1FFAR3
Hydrochloric Acid SCHEMBL23094114 0.86 DGAT1 (0.50) DGAT1FFAR3
SCHEMBL28167619 0.81 DGAT1 (0.44) DGAT1RIPK1
SCHEMBL9446531 0.79 DGAT1 (0.43) DGAT1CYP2C19RIPK1
SCHEMBL27474067 0.79 DGAT1 (0.43) DGAT1RIPK1
SCHEMBL21826042 0.78 DGAT1 (0.39) DGAT1
SCHEMBL25325201 0.78 DGAT1 (0.43) DGAT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 151 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2903979-B1 NOVEL COMPOUNDS, THEIR PREPARATION AND THEIR USES INHIBIKASE THERAPEUTICS INC (US) 2020-08-19 EP claimed
CN-111162313-A Polymer electrolyte and lithium ion battery 珠海冠宇电池有限公司 2020-05-15 CN claimed
EP-3802500-B1 MELANOCORTIN SUBTYPE-2 RECEPTOR (MC2R) ANTAGONISTS AND USES THEREOF CRINETICS PHARMACEUTICALS INC (US) 2026-05-27 EP disclosed
US-12492182-B2 Hydroxytriazine compounds and pharmaceutical use thereof JAPAN TOBACCO INC. (JP) 2025-12-09 US disclosed
US-12479828-B2 Melanocortin subtype-2 receptor (MC2R) antagonists and uses thereof Crinetics Pharmaceuticals, Inc. (US) 2025-11-25 US disclosed
EP-4550995-A2 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES Universal Display Corporation (US) 2025-05-07 EP disclosed
EP-3492528-B1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORP (US) 2025-04-30 EP disclosed
WO-2025048759-A1 BENZIMIDAZOLE DERIVATIVES AS MPGES-1 INHIBITORS ICOSYN THERAPEUTICS SAGLIK TEKNOLOJILERI ANONIM SIRKETI (TR) 2025-03-06 WO disclosed
WO-2025026158-A1 COMPOUNDS HAVING PTPN2 INHIBITORY EFFECTS AND USE THEREOF 杭州中美华东制药有限公司 2025-02-06 WO disclosed
US-12129221-B2 Difluoro phenyl amide RIP1 inhibitor SIRONAX LTD (KY) 2024-10-29 US disclosed
CN-112533904-B Melanocortin subtype-2 receptor (MC 2R) antagonists and uses thereof 克林提克斯医药股份有限公司 2024-10-29 CN disclosed
EP-2254889-B1 PROTEIN KINASE INHIBITORS AND USE THEREOF MERCK PATENT GMBH (DE) 2012-12-19 EP disclosed
EP-2504317-A1 POTASSIUM CHANNEL MODULATORS Abbott Laboratories (US) 2012-10-03 EP disclosed
CN-102666495-A Potassium channel modulators ABBOTT LAB 2012-09-12 CN disclosed
WO-2011066168-A1 POTASSIUM CHANNEL MODULATORS ABBOTT LABORATORIES (US) 2011-06-03 WO disclosed
US-20110124642-A1 POTASSIUM CHANNEL MODULATORS ABBOTT LABORATORIES (US) 2011-05-26 US disclosed
US-20110053906-A1 PROTEIN KINASE INHIBITORS AND USE THEREOF MERCK PATENT GMBH (DE) 2011-03-03 US disclosed
EP-2254889-A1 PROTEIN KINASE INHIBITORS AND USE THEREOF Merck Patent GmbH (DE) 2010-12-01 EP disclosed
US-20100022513-A1 ORGANIC COMPOUNDS NOVARTIS AG (CH) 2010-01-28 US disclosed
WO-2009108670-A1 PROTEIN KINASE INHIBITORS AND USE THEREOF MERCK SERONO S.A. (CH) 2009-09-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100022513-A1 ORGANIC COMPOUNDS DGAT1, DGAT2, SOAT1 DGAT1 1/4885CYP2C19 692/4885RIPK1 3322/4885
US-12492182-B2 Hydroxytriazine compounds and pharmaceutical use thereof PTGS1, PTGIS, PTGES DGAT1 1971/4885CYP2C19 2002/4885RIPK1 2493/4885
US-12129221-B2 Difluoro phenyl amide RIP1 inhibitor RIPK1, RIPK3, RIPK4 DGAT1 844/4885CYP2C19 4335/4885RIPK1 1/4885
US-20110124642-A1 POTASSIUM CHANNEL MODULATORS KCNQ1, KCNQ2, KCNQ3 DGAT1 2527/4885CYP2C19 2407/4885RIPK1 2626/4885
US-12479828-B2 Melanocortin subtype-2 receptor (MC2R) antagonists and uses thereof MC3R, MC1R, MC2R DGAT1 3220/4885CYP2C19 1504/4885RIPK1 4491/4885
US-20110053906-A1 PROTEIN KINASE INHIBITORS AND USE THEREOF MAP4K2, MAP3K20, MAP4K1 DGAT1 3952/4885CYP2C19 3420/4885RIPK1 417/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.