Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 5/20 | 0.35 |
| ▸ | RXRB | P28702 | 2/20 | 0.34 |
| ▸ | RXRG | P48443 | 2/20 | 0.34 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | BTK | Q06187 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ASPH | Q12797 | 1/20 | 0.33 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | F11 | P03951 | 1/20 | 0.32 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.32 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.32 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.32 |
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.32 |
| ▸ | LPL | P06858 | 1/20 | 0.32 |
| ▸ | RARB | P10826 | 3/20 | 0.31 |
| ▸ | RARG | P13631 | 3/20 | 0.31 |
| ▸ | RARA | P10276 | 2/20 | 0.31 |
| ▸ | LIPE | Q05469 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10059440 | 0.94 | RXRA (0.35) | RXRARXRBRXRGJAK2BTK | |
| SCHEMBL1710489 | 0.87 | DGAT1 (0.35) | JAK2BTKROCK1F2F11 | |
| SCHEMBL12942090 | 0.86 | GABRP (0.34) | RXRARXRBRXRGKDM4EF2 | |
| SCHEMBL16113731 | 0.84 | UCHL1 (0.34) | JAK2BTKKDM4EROCK1LIPE | |
| SCHEMBL22468536 | 0.84 | GAA (0.37) | JAK2BTKROCK1LIPE | |
| SCHEMBL10059293 | 0.83 | KDM4E (0.35) | RXRARXRBRXRGKDM4EF2 | |
| SCHEMBL17239587 | 0.82 | TSHR (0.35) | RXRAJAK2BTKNOTUM | |
| SCHEMBL26670863 | 0.81 | DGAT1 (0.35) | JAK2BTKROCK1F2F11 | |
| SCHEMBL18107884 | 0.80 | LIPG (0.36) | KDM4EF2F11PRSS1PRSS2 | |
| SCHEMBL26153576 | 0.80 | LPL (0.39) | JAK2BTKLIPGLPL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4276095-A2 | PROCESSES FOR PREPARING ASK1 INHIBITORS | Gilead Sciences, Inc. (US) | 2023-11-15 | — | — | EP | disclosed |
| CN-112225699-B | Process for preparing ASK1 inhibitors | 吉利德科学公司 | 2023-11-14 | — | — | CN | disclosed |
| EP-3693366-B1 | PROCESSES FOR PREPARING ASK1 INHIBITORS | GILEAD SCIENCES INC (US) | 2023-06-28 | — | — | EP | disclosed |
| US-20220135527-A1 | PROCESSES FOR PREPARING ASK1 INHIBITORS | GILEAD SCIENCES, INC. | 2022-05-05 | — | — | US | disclosed |
| US-11261161-B2 | Processes for preparing ASK1 inhibitors | GILEAD SCIENCES, INC. (US) | 2022-03-01 | — | — | US | disclosed |
| CN-112225699-A | Process for preparing ASK1 inhibitors | 吉利德科学公司 | 2021-01-15 | — | — | CN | disclosed |
| EP-3237404-B1 | PROCESSES FOR PREPARING ASK1 INHIBITORS | GILEAD SCIENCES INC (US) | 2020-11-11 | — | — | EP | disclosed |
| CN-107108519-B | Process for preparing ASK1 inhibitors | 吉利德科学公司 | 2020-11-03 | — | — | CN | disclosed |
| US-20200283393-A1 | PROCESSES FOR PREPARING ASK1 INHIBITORS | GILEAD SCIENCES, INC. | 2020-09-10 | — | — | US | disclosed |
| EP-3693366-A1 | PROCESSES FOR PREPARING ASK1 INHIBITORS | Gilead Sciences, Inc. (US) | 2020-08-12 | — | — | EP | disclosed |
| US-10604490-B2 | Processes for preparing ASK1 inhibitors | GILEAD SCIENCES, INC. (US) | 2020-03-31 | — | — | US | disclosed |
| US-20180022708-A1 | PROCESSES FOR PREPARING ASK1 INHIBITORS | GILEAD SCIENCES, INC. | 2018-01-25 | — | — | US | disclosed |
| EP-3237404-A1 | PROCESSES FOR PREPARING ASK1 INHIBITORS | Gilead Sciences, Inc. (US) | 2017-11-01 | — | — | EP | disclosed |
| US-9771328-B2 | Processes for preparing ASK1 inhibitors | GILEAD SCIENCES, INC. (US) | 2017-09-26 | — | — | US | disclosed |
| US-20170233350-A1 | PROCESSES FOR PREPARING ASK1 INHIBITORS | GILEAD SCIENCES, INC. | 2017-08-17 | — | — | US | disclosed |
| US-9586933-B2 | Processes for preparing ASK1 inhibitors | GILEAD SCIENCES, INC. (US) | 2017-03-07 | — | — | US | disclosed |
| US-20160244430-A1 | Processes for preparing ASK1 inhibitors | GILEAD SCIENCES, INC. (US) | 2016-08-25 | — | — | US | disclosed |
| WO-2016106384-A1 | PROCESSES FOR PREPARING ASK1 INHIBITORS | GILEAD SCIENCES, INC. (US) | 2016-06-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170233350-A1 | PROCESSES FOR PREPARING ASK1 INHIBITORS | MAP3K1, MAP3K6, MAP3K7 | RXRA 3350/4885RXRB 3256/4885RXRG 3313/4885 |
| US-20200283393-A1 | PROCESSES FOR PREPARING ASK1 INHIBITORS | MAP3K1, MAP3K6, MAP3K7 | RXRA 3350/4885RXRB 3256/4885RXRG 3313/4885 |
| US-10604490-B2 | Processes for preparing ASK1 inhibitors | MAP3K1, MAP3K6, MAP3K7 | RXRA 3350/4885RXRB 3256/4885RXRG 3313/4885 |
| US-11261161-B2 | Processes for preparing ASK1 inhibitors | MAP3K1, MAP3K6, MAP3K7 | RXRA 3350/4885RXRB 3256/4885RXRG 3313/4885 |
| US-20180022708-A1 | PROCESSES FOR PREPARING ASK1 INHIBITORS | MAP3K1, MAP3K6, MAP3K7 | RXRA 3350/4885RXRB 3256/4885RXRG 3313/4885 |
| US-20160244430-A1 | Processes for preparing ASK1 inhibitors | MAP3K1, MAP3K6, MAP3K7 | RXRA 3350/4885RXRB 3256/4885RXRG 3313/4885 |
| US-20220135527-A1 | PROCESSES FOR PREPARING ASK1 INHIBITORS | MAP3K1, MAP3K6, MAP3K7 | RXRA 3350/4885RXRB 3256/4885RXRG 3313/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.