Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.51 |
| ▸ | HTR2C | P28335 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.36 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17907935 | 0.82 | MAOA (0.36) | HTR2AHTR2CKDM4EPOLBKMT2A | |
| SCHEMBL17907932 | 0.80 | SIGMAR1 (0.41) | HTR2AHTR2CKDM4EALDH1A1HSD17B10 | |
| SCHEMBL9261564 | 0.79 | NOTUM (0.57) | HTR2AHTR2CKDM4EALDH1A1HPGD | |
| SCHEMBL13279280 | 0.77 | SIGMAR1 (0.42) | HTR2AHTR2CKDM4EALDH1A1HPGD | |
| SCHEMBL4048826 | 0.77 | HTR2A (0.62) | HTR2AHTR2CKDM4EALDH1A1HPGD | |
| SCHEMBL17907930 | 0.77 | HTR2A (0.48) | HTR2AHTR2CKDM4EALDH1A1HPGD | |
| SCHEMBL235219 | 0.74 | NOTUM (0.59) | HTR2AHTR2C | |
| SCHEMBL26839172 | 0.73 | HTR2A (0.61) | HTR2AHTR2CKDM4EALDH1A1HPGD | |
| SCHEMBL26838992 | 0.72 | HTR2A (0.77) | HTR2AHTR2CKDM4EALDH1A1HPGD | |
| SCHEMBL4049250 | 0.72 | HTR2A (0.59) | HTR2AHTR2CKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2697223-B1 | 7-(HETEROARYL-AMINO)-6,7,8,9-TETRAHYDROPYRIDO[1,2-A]INDOL ACETIC ACID DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS | ACTELION PHARMACEUTICALS LTD (CH) | 2016-07-13 | — | — | EP | disclosed |