Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | F9 | P00740 | 2/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13279280 | 0.81 | SIGMAR1 (0.42) | SIGMAR1ALDH1A1KDM4EHSD17B10NOTUM | |
| SCHEMBL17907930 | 0.81 | HTR2A (0.48) | ALDH1A1KDM4EHSD17B10NOTUMHTR2A | |
| SCHEMBL17907920 | 0.80 | HTR2A (0.51) | ALDH1A1KDM4EHSD17B10SMN1; SMN2CYP2A6 | |
| SCHEMBL235219 | 0.78 | NOTUM (0.59) | SIGMAR1NOTUMHTR2AHTR2C | |
| SCHEMBL9844702 | 0.77 | NOTUM (0.62) | SIGMAR1ALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL17907965 | 0.71 | HTR2A (0.48) | NOTUMHTR2AHTR2CRXFP1 | |
| SCHEMBL9259274 | 0.69 | KDM4E (0.39) | SIGMAR1ALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL17907947 | 0.68 | ALDH1A1 (0.38) | ALDH1A1NOTUML3MBTL1 | |
| SCHEMBL9259282 | 0.67 | NOTUM (0.62) | ALDH1A1KDM4EHSD17B10NOTUMSMN1; SMN2 | |
| SCHEMBL4705400 | 0.65 | HTR2A (0.68) | SIGMAR1KDM4EHSD17B10HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2697223-B1 | 7-(HETEROARYL-AMINO)-6,7,8,9-TETRAHYDROPYRIDO[1,2-A]INDOL ACETIC ACID DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS | ACTELION PHARMACEUTICALS LTD (CH) | 2016-07-13 | — | — | EP | disclosed |