Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | DAO | P14920 | 1/20 | 0.32 |
| ▸ | PER2 | O15055 | 3/20 | 0.32 |
| ▸ | CRY2 | Q49AN0 | 3/20 | 0.32 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.31 |
| ▸ | HTR3B | O95264 | 1/20 | 0.31 |
| ▸ | HTR3A | P46098 | 1/20 | 0.31 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.31 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 2/20 | 0.30 |
| ▸ | HTR2C | P28335 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13279354 | 0.87 | NOTUM (0.39) | SIGMAR1NOTUMDAOHTR2AHTR2C | |
| SCHEMBL17907930 | 0.81 | HTR2A (0.48) | KDM4EALDH1A1HPGDHSD17B10NOTUM | |
| SCHEMBL17907932 | 0.81 | SIGMAR1 (0.41) | SIGMAR1KDM4EALDH1A1HSD17B10NOTUM | |
| SCHEMBL235219 | 0.78 | NOTUM (0.59) | SIGMAR1NOTUMHTR2AHTR2C | |
| SCHEMBL17907920 | 0.77 | HTR2A (0.51) | KDM4EALDH1A1HPGDHSD17B10HTR2A | |
| SCHEMBL18202191 | 0.75 | SIGMAR1 (0.48) | SIGMAR1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL24916793 | 0.73 | SIGMAR1 (0.50) | SIGMAR1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL17907965 | 0.71 | HTR2A (0.48) | NOTUMDAOHTR2AHTR2C | |
| SCHEMBL17907947 | 0.71 | ALDH1A1 (0.38) | ALDH1A1NOTUM | |
| SCHEMBL9844695 | 0.70 | SIGMAR1 (0.39) | SIGMAR1KDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2697223-B1 | 7-(HETEROARYL-AMINO)-6,7,8,9-TETRAHYDROPYRIDO[1,2-A]INDOL ACETIC ACID DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS | ACTELION PHARMACEUTICALS LTD (CH) | 2016-07-13 | — | — | EP | disclosed |
| EP-2697223-A1 | 7-(HETEROARYL-AMINO)-6,7,8,9-TETRAHYDROPYRIDO[1,2-A]INDOL ACETIC ACID DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS | Actelion Pharmaceuticals Ltd. (CH) | 2014-02-19 | — | — | EP | disclosed |
| WO-2012140612-A1 | 7-(HETEROARYL-AMINO)-6,7,8,9-TETRAHYDROPYRIDO[1,2-A]INDOL ACETIC ACID DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS | ACTELION PHARMACEUTICALS LTD (CH) | 2012-10-18 | — | — | WO | disclosed |