Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | QDPR | P09417 | 1/20 | 0.35 |
| ▸ | HPSE | Q9Y251 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14158855 | 0.89 | GPR119 (0.50) | GPR119 | |
| SCHEMBL14695343 | 0.83 | MMP2 (0.44) | HDAC6PTGS2GPR119MMP2MMP3 | |
| SCHEMBL14695968 | 0.82 | GPR119 (0.50) | GPR119 | |
| SCHEMBL14695345 | 0.82 | MMP2 (0.44) | HDAC6GPR119MMP2MMP3HDAC3 | |
| SCHEMBL17965159 | 0.82 | LIPC (0.42) | DPP4DPP7GPR119MMP2MMP3 | |
| SCHEMBL17965046 | 0.79 | S1PR1 (0.43) | HDAC6DPP4DPP7GPR119S1PR1 | |
| SCHEMBL17993970 | 0.79 | PTGS2 (0.41) | HDAC6PTGS2HDAC3HDAC8MAPT | |
| Trifluoroacetic Acid SCHEMBL14158710 | 0.79 | TBK1 (0.40) | HDAC6DPP4DPP7PTGS2GPR119 | |
| SCHEMBL17965205 | 0.78 | GPR119 (0.46) | HDAC6DPP4DPP7GPR119S1PR1 | |
| SCHEMBL14695393 | 0.77 | GPR119 (0.48) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2718279-B1 | NOVEL COMPOUNDS AS MODULATORS OF GPR-119 | RHIZEN PHARMACEUTICALS SA (CH) | 2016-08-10 | — | — | EP | claimed |