Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.35 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | MITF | O75030 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TTR | P02766 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | RAD52 | P43351 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5707080 | 0.81 | CYP1A2 (0.35) | CDK1HRH4MAPK1CYP2D6CYP2C19 | |
| SCHEMBL5405380 | 0.79 | HRH4 (0.34) | CDK1HRH4GAAMEN1KMT2A | |
| SCHEMBL5418378 | 0.77 | ALDH1A1 (0.35) | CDK1HRH4KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL14445360 | 0.77 | CNR1 (0.34) | CDK1HRH4SHMT2MAPK1KDM4E | |
| SCHEMBL14445306 | 0.75 | KDM4E (0.37) | CDK1KMT2AMAPK1KDM4EHSD17B10 | |
| SCHEMBL14445364 | 0.75 | MAPK1 (0.33) | CDK1GAAKMT2AMAPK1ATM | |
| SCHEMBL5418383 | 0.74 | CDK1 (0.30) | CDK1 | |
| SCHEMBL5418385 | 0.74 | CDK1 (0.30) | CDK1 | |
| SCHEMBL5399863 | 0.74 | LMNA (0.32) | CDK1KDM4EALDH1A1LMNA | |
| SCHEMBL14445231 | 0.73 | CCNA2 (0.30) | MEN1KMT2AAURKACCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1011619-B2 | DYEING COMPOSITION FOR KERATIN FIBRES | OREAL (FR) | 2012-07-04 | — | — | EP | claimed |
| EP-1345580-B9 | COMPOSITION FOR OXIDATION DYEING OF KERATINOUS FIBRES COMPRISING A DIAMINO PYRAZOLE AND A CARBONYL COMPOUND | OREAL (FR) | 2009-11-25 | — | — | EP | claimed |
| EP-1345580-B1 | COMPOSITION FOR OXIDATION DYEING OF KERATINOUS FIBRES COMPRISING A DIAMINO PYRAZOLE AND A CARBONYL COMPOUND | OREAL (FR) | 2006-06-07 | — | — | EP | claimed |
| EP-1011619-B1 | DYEING COMPOSITION FOR KERATIN FIBRES | OREAL (FR) | 2005-09-14 | — | — | EP | claimed |
| EP-1345579-B1 | COMPOSITION FOR OXIDATION DYEING OF KERATINOUS FIBRES COMPRISING AN AMINO PYRAZOLE AND A MINERAL COMPOUND | OREAL (FR) | 2005-06-29 | — | — | EP | claimed |
| US-20040237219-A1 | Composition for oxidation dyeing of keratinous fibres comprising at least a 4,5 or 3,4-diamino pyrazole or a triamino pyrazole and at least a particular cellulose compound, and dyeing method | L'OREAL (FR) | 2004-12-02 | — | — | US | claimed |
| US-6780203-B1 | DIAMINOPYRAZOLE DERIVATIVE OXIDATION HAIR DYE AND 3-AMINO-2-CHLORO-6- METHYLPHENOL OR SALT COUPLER | L'ORéAL S.A. (FR) | 2004-08-24 | — | — | US | claimed |
| US-20040088800-A1 | Composition for the oxidation dyeing of keratinous fibres comprising a diamino pyrazole and a carbonyl compound | L'OREAL (FR) | 2004-05-13 | — | — | US | claimed |
| US-20040074014-A1 | Composition for oxidation dyeing of keratinous fibres comprising an amino pyrazole and a mineral compound | L'OREAL (FR) | 2004-04-22 | — | — | US | claimed |
| EP-1404288-A2 | COMPOSITION FOR OXIDATION DYEING OF KERATINOUS FIBRES COMPRISING A AMINO PYRAZOLE AND A CELLULOSE COMPOUND | L'OREAL (FR) | 2004-04-07 | — | — | EP | claimed |
| EP-1345579-A1 | COMPOSITION FOR OXIDATION DYEING OF KERATINOUS FIBRES COMPRISING AN AMINO PYRAZOLE AND A MINERAL COMPOUND | L'OREAL (FR) | 2003-09-24 | — | — | EP | claimed |
| EP-1345580-A1 | COMPOSITION FOR OXIDATION DYEING OF KERATINOUS FIBRES COMPRISING A DIAMINO PYRAZOLE AND A CARBONYL COMPOUND | L'OREAL (FR) | 2003-09-24 | — | — | EP | claimed |
| WO-2002051373-A1 | COMPOSITION FOR OXIDATION DYEING OF KERATINOUS FIBRES COMPRISING A DIAMINO PYRAZOLE AND A CARBONYL COMPOUND | L'OREAL (FR) | 2002-07-04 | — | — | WO | claimed |
| WO-2002051371-A1 | COMPOSITION FOR OXIDATION DYEING OF KERATINOUS FIBRES COMPRISING AN AMINO PYRAZOLE AND A MINERAL COMPOUND | L'OREAL (FR) | 2002-07-04 | — | — | WO | claimed |
| WO-2002051372-A2 | COMPOSITION FOR OXIDATION DYEING OF KERATINOUS FIBRES COMPRISING A AMINO PYRAZOLE AND A CELLULOSE COMPOUND | L'OREAL (FR) | 2002-07-04 | — | — | WO | claimed |
| EP-1011619-A1 | DYEING COMPOSITION FOR KERATIN FIBRES | L'OREAL (FR) | 2000-06-28 | — | — | EP | claimed |
| WO-1999011231-A1 | DYEING COMPOSITION FOR KERATIN FIBRES | L'OREAL (FR) | 1999-03-11 | — | — | WO | claimed |
| US-5785717-A | Composition for the oxidation dyeing of keratin fibers, comprising a diaminopyrazole derivative and a heterocyclic coupler, and dyeing process | L'OREAL (FR) | 1998-07-28 | — | — | US | claimed |
| EP-0728464-B1 | Composition for dyeing keratinous fibers comprising a diaminopyrazole derivative and a heterocyclic coupleur and dyeing process | OREAL (FR) | 1997-07-30 | — | — | EP | claimed |
| EP-0728464-A1 | Composition for dyeing keratinous fibers comprising a diaminopyrazole derivative and a heterocyclic coupleur and dyeing process | L'OREAL (FR) | 1996-08-28 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040237219-A1 | Composition for oxidation dyeing of keratinous fibres comprising at least a 4,5 or 3,4-diamino pyrazole or a triamino pyrazole and at least a particular cellulose compound, and dyeing method | KRT18, TUBB3, PPOX | CDK1 1081/4885HRH4 1038/4885SHMT2 370/4885 |
| US-20040074014-A1 | Composition for oxidation dyeing of keratinous fibres comprising an amino pyrazole and a mineral compound | KRT18, TUBB3, COX5A | CDK1 1168/4885HRH4 773/4885SHMT2 348/4885 |
| US-20040088800-A1 | Composition for the oxidation dyeing of keratinous fibres comprising a diamino pyrazole and a carbonyl compound | KRT18, TUBB3, COX5A | CDK1 824/4885HRH4 797/4885SHMT2 353/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.