Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.32 |
| ▸ | IDO1 | P14902 | 2/20 | 0.31 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.31 |
| ▸ | HTR3B | O95264 | 1/20 | 0.31 |
| ▸ | HTR3A | P46098 | 1/20 | 0.31 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.31 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1796084 | 0.78 | MAP2K1 (0.32) | IDO1 | |
| SCHEMBL9691797 | 0.77 | ALDH1A1 (0.38) | IDO1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7929426 | 0.77 | NOTUM (0.34) | NOTUMIDO1HTR3EHTR3BHTR3A | |
| SCHEMBL977694 | 0.77 | ADRB2 (0.42) | NOTUMIDO1HTR3EHTR3BHTR3A | |
| SCHEMBL7071048 | 0.75 | IDO1 (0.33) | NOTUMIDO1HTR3EHTR3BHTR3A | |
| SCHEMBL1799126 | 0.74 | TSHR (0.43) | IDO1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL29025677 | 0.74 | KDM1A (0.33) | NOTUMIDO1HTR3EHTR3BHTR3A | |
| SCHEMBL19268220 | 0.74 | RAPGEF4 (0.41) | NOTUMIDO1HTR3EHTR3BHTR3A | |
| SCHEMBL31173894 | 0.74 | TSHR (0.43) | IDO1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL3175500 | 0.73 | NOTUM (0.33) | NOTUMIDO1HTR3EHTR3BHTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240382454-A1 | ANTIPARASITIC ISOXAZOLINE COMPOUNDS, LONG-ACTING INJECTABLE FORMULATIONS COMPRISING THEM, METHODS AND USES THEREOF | Boehringer Ingelheim Animal Health USA Inc. (US) | 2024-11-21 | — | — | US | disclosed |
| US-12083100-B1 | Antiparasitic isoxazoline compounds, long-acting injectable formulations comprising them, methods and uses thereof | Boehringer Ingelheim Animal Health USA Inc. (US) | 2024-09-10 | — | — | US | disclosed |
| CN-115959979-A | Preparation method of 3-chloro-4-fluoro-5-trifluoromethyl trifluoroacetophenone | 南京正荣医药化学有限公司 | 2023-04-14 | — | — | CN | disclosed |
| US-11497732-B2 | Antiparasitic isoxazoline compounds, long-acting injectable formulations comprising them, methods and uses thereof | Boehringer Ingelheim Animal Health USA Inc. (US) | 2022-11-15 | — | — | US | disclosed |
| CN-114573573-A | Antiparasitic isoxazoline compounds, long-acting injectable formulations containing them, methods and uses thereof | 勃林格殷格翰动物保健美国公司 | 2022-06-03 | — | — | CN | disclosed |
| US-11324220-B2 | Process for the preparation of isoxazoline compounds | Boehringer Ingelheim Animal Health USA Inc. (US) | 2022-05-10 | — | — | US | disclosed |
| CN-109068651-B | Antiparasitic isoxazoline compounds, long-acting injectable formulations containing them, methods and uses thereof | 勃林格殷格翰动物保健美国公司 | 2022-03-01 | — | — | CN | disclosed |
| EP-3440062-B1 | PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY ENRICHED ISOXAZOLINE COMPOUNDS - CRYSTALLINE TOLUENE SOLVATE OF (S)-AFOXOLANER | BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC (US) | 2021-10-06 | — | — | EP | disclosed |
| EP-3419424-B1 | LONG-ACTING INJECTABLE FORMULATIONS COMPRISING ANTIPARASITIC ISOXAZOLINE COMPOUNDS AND USE THEREOF | BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC (US) | 2021-04-28 | — | — | EP | disclosed |
| EP-3763211-A1 | ANTIPARASITIC ISOXAZOLINE COMPOUNDS, LONG-ACTING INJECTABLE FORMULATIONS COMPRISING THEM, METHODS AND USES THEREOF | Boehringer Ingelheim Animal Health USA Inc. (US) | 2021-01-13 | — | — | EP | disclosed |
| WO-2017176948-A1 | PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY ENRICHED ISOXAZOLINE COMPOUNDS - CRYSTALLINE TOLUENE SOLVATE OF (S)-AFOXOLANER | MERIAL, INC. (US) | 2017-10-12 | — | — | WO | disclosed |
| WO-2017147352-A1 | ANTIPARASITIC ISOXAZOLINE COMPOUNDS, LONG-ACTING INJECTABLE FORMULATIONS COMPRISING THEM, METHODS AND USES THEREOF | MERIAL, INC. (US) | 2017-08-31 | — | — | WO | disclosed |
| US-20170239218-A1 | ANTIPARASITIC ISOXAZOLINE COMPOUNDS, LONG-ACTING INJECTABLE FORMULATIONS COMPRISING THEM, METHODS AND USES THEREOF | MERIAL INC. (US) | 2017-08-24 | — | — | US | disclosed |
| US-8987464-B2 | Isoxazoline-substituted benzamide compound and pesticide | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2015-03-24 | — | — | US | disclosed |
| US-20140135496-A1 | ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2014-05-15 | — | — | US | disclosed |
| US-8673951-B2 | Isoxazoline-substituted benzamide compound and pesticide | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2014-03-18 | — | — | US | disclosed |
| EP-1932836-B1 | ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND HARMFUL ORGANISM-CONTROLLING AGENT | NISSAN CHEMICAL IND LTD (JP) | 2013-11-06 | — | — | EP | disclosed |
| US-20110144334-A1 | ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2011-06-16 | — | — | US | disclosed |
| US-7951828-B1 | Isoxazoline-substituted benzamide compound and pesticide | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2011-05-31 | — | — | US | disclosed |
| EP-1932836-A1 | ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND HARMFUL ORGANISM-CONTROLLING AGENT | Nissan Chemical Industries, Ltd. (JP) | 2008-06-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110144334-A1 | ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE | OR10J3, OR51E2, ORMDL3 | NOTUM 223/4885IDO1 621/4885HTR3E 2340/4885 |
| US-12083100-B1 | Antiparasitic isoxazoline compounds, long-acting injectable formulations comprising them, methods and uses thereof | IL17A, MMP17, MMP1 | NOTUM 1403/4885IDO1 32/4885HTR3E 3112/4885 |
| US-20240382454-A1 | ANTIPARASITIC ISOXAZOLINE COMPOUNDS, LONG-ACTING INJECTABLE FORMULATIONS COMPRISING THEM, METHODS AND USES THEREOF | IL17A, MMP17, MMP1 | NOTUM 1403/4885IDO1 32/4885HTR3E 3112/4885 |
| US-11497732-B2 | Antiparasitic isoxazoline compounds, long-acting injectable formulations comprising them, methods and uses thereof | IL17A, MMP17, MMP1 | NOTUM 1403/4885IDO1 32/4885HTR3E 3112/4885 |
| US-20140135496-A1 | ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE | OR10J3, OR51E2, ODC1 | NOTUM 646/4885IDO1 684/4885HTR3E 2032/4885 |
| US-11324220-B2 | Process for the preparation of isoxazoline compounds | CYP3A7, CYP3A4, CYP3A5 | NOTUM 2528/4885IDO1 8/4885HTR3E 1276/4885 |
| US-20170239218-A1 | ANTIPARASITIC ISOXAZOLINE COMPOUNDS, LONG-ACTING INJECTABLE FORMULATIONS COMPRISING THEM, METHODS AND USES THEREOF | IL17A, MMP17, MMP1 | NOTUM 1403/4885IDO1 32/4885HTR3E 3112/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.