SCHEMBL18029448

SCHEMBL18029448

BN1CCN(c2ccc(N3CCN(B)CC3)cc2)CC1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 5/20 0.44
▸ MAPT P10636 5/20 0.44
▸ KDM4E B2RXH2 5/20 0.44
▸ GFER P55789 3/20 0.44
▸ ADRA2C P18825 3/20 0.44
▸ GAA P10253 3/20 0.44
▸ HTT P42858 2/20 0.44
▸ KMT2A Q03164 2/20 0.44
▸ F2 P00734 2/20 0.44
▸ PRSS1 P07477 2/20 0.44
▸ PRSS2 P07478 2/20 0.44
▸ PRSS3 P35030 2/20 0.44
▸ TMPRSS6 Q8IU80 2/20 0.44
▸ ST14 Q9Y5Y6 2/20 0.44
▸ LMNA P02545 1/20 0.44
▸ MAPK1 P28482 1/20 0.44
▸ TDP1 Q9NUW8 1/20 0.44
▸ PTK2B Q14289 1/20 0.44
▸ ESR2 Q92731 1/20 0.44
▸ ADRA2A P08913 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19596993 0.88 ALDH1A1 (0.38) ALDH1A1MAPTKDM4EGFERADRA2C
SCHEMBL7258870 0.73 LMNA (0.64) ALDH1A1MAPTGAAKMT2ALMNA
SCHEMBL3414344 0.71 ADRB1 (0.70) ALDH1A1MAPTKDM4EGFERADRA2C
SCHEMBL870704 0.71 HTR3E (0.70) ALDH1A1MAPTKDM4EGFERGAA
SCHEMBL14345952 0.71 AKR1C3 (0.57) ALDH1A1MAPTKDM4EGFERADRA2C
SCHEMBL16924853 0.69 LMNA (0.67) ALDH1A1MAPTGAAKMT2ALMNA
SCHEMBL6887590 0.69 ALDH1A1 (0.71) ALDH1A1MAPTKDM4EGFERGAA
SCHEMBL18558822 0.69 — —
SCHEMBL14149145 0.67 MAPT (0.63) ALDH1A1MAPTKDM4EGFERADRA2C
SCHEMBL21565473 0.67 ALDH1A1 (0.54) ALDH1A1MAPTKDM4EGAAHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10858377-B2 Multivinylaminosilanes as branching agents for functionalized elastomeric polymers TRINSEO EUROPE GMBH (CH) 2020-12-08 — — US disclosed
US-10787562-B2 Silane-mediated enhancement of rubber storage stability TRINSEO EUROPE GMBH (CH) 2020-09-29 — — US disclosed
US-20200131358-A1 In-Situ Polymer Blend for a Tire SYNTHOS DWORY 7 SPOLKA Z OGRANICZONA ODPOWIEDZIALNOSCIA (PL) 2020-04-30 — — US disclosed
US-20200071505-A1 IN-SITU POLYMER BLEND FOR A TIRE TRINSEO EUROPE GMBH (CH) 2020-03-05 — — US disclosed
US-20200055881-A1 MULTIVINYLAMINOSILANES AS BRANCHING AGENTS FOR FUNCTIONALIZED ELASTOMERIC POLYMERS TRINSEO EUROPE GMBH (CH) 2020-02-20 — — US disclosed
EP-3059240-B1 Multivinylaminosilanes as branching agents for functionalized elastomeric polymers TRINSEO EUROPE GMBH (CH) 2019-10-30 — — EP disclosed
EP-3471971-B1 IN-SITU POLYMER BLEND FOR A TIRE TRINSEO EUROPE GMBH (CH) 2019-10-09 — — EP disclosed
US-10344147-B2 Functionalized polymer blend for a tire TRINSEO EUROPE GMBH (CH) 2019-07-09 — — US disclosed
US-20190169406-A1 SILANE-MEDIATED ENHANCEMENT OF RUBBER STORAGE STABILITY TRINSEO EUROPE GMBH (CH) 2019-06-06 — — US disclosed
WO-2019020419-A1 IN-SITU POLYMER BLEND FOR A TIRE TRINSEO EUROPE GMBH (CH) 2019-01-31 — — WO disclosed
EP-3059099-B1 A polymer blend for a tire TRINSEO EUROPE GMBH (CH) 2018-01-17 — — EP disclosed
WO-2017216344-A1 SILANE-MEDIATED ENHANCEMENT OF RUBBER STORAGE STABILITY TRINSEO EUROPE GMBH (CH) 2017-12-21 — — WO disclosed
EP-3257869-A1 SILANE-MEDIATED ENHANCEMENT OF RUBBER STORAGE STABILITY Trinseo Europe GmbH (CH) 2017-12-20 — — EP disclosed
EP-3059256-B1 A functionalized polymer blend for a tire TRINSEO EUROPE GMBH (CH) 2017-11-15 — — EP disclosed
WO-2016131914-A1 A POLYMER BLEND FOR A TIRE TRINSEO EUROPE GMBH (CH) 2016-08-25 — — WO disclosed
WO-2016131913-A1 A FUNCTIONALIZED POLYMER BLEND FOR A TIRE TRINSEO EUROPE GMBH (CH) 2016-08-25 — — WO disclosed
WO-2016131590-A1 MULTIVINYLAMINOSILANES AS BRANCHING AGENTS FOR FUNCTIONALIZED ELASTOMERIC POLYMERS TRINSEO EUROPE GMBH (CH) 2016-08-25 — — WO disclosed
EP-3059256-A1 A functionalized polymer blend for a tire Trinseo Europe GmbH (CH) 2016-08-24 — — EP disclosed
EP-3059099-A1 A polymer blend for a tire Trinseo Europe GmbH (CH) 2016-08-24 — — EP disclosed
EP-3059240-A1 Multivinylaminosilanes as branching agents for functionalized elastomeric polymers Trinseo Europe GmbH (CH) 2016-08-24 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200055881-A1 MULTIVINYLAMINOSILANES AS BRANCHING AGENTS FOR FUNCTIONALIZED ELASTOMERIC POLYMERS PRUNE1, GNE, TERB1 ALDH1A1 2357/4885MAPT 3114/4885KDM4E 1497/4885
US-10858377-B2 Multivinylaminosilanes as branching agents for functionalized elastomeric polymers GMNN, GNE, MSN ALDH1A1 2672/4885MAPT 2750/4885KDM4E 2484/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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