Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 12/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 12/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 8/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12620442 | 0.87 | ALDH1A1 (0.41) | ALDH1A1KMT2AMEN1L3MBTL1CYP1A2 | |
| SCHEMBL12672764 | 0.83 | ALDH1A1 (0.44) | ALDH1A1KMT2AMEN1L3MBTL1CYP1A2 | |
| SCHEMBL1804823 | 0.83 | MEN1 (0.46) | ALDH1A1KMT2AMEN1L3MBTL1CYP1A2 | |
| SCHEMBL1804096 | 0.82 | PIN1 (0.45) | ALDH1A1KMT2AMEN1L3MBTL1CYP2C9 | |
| SCHEMBL22534771 | 0.82 | CASP1 (0.44) | ALDH1A1KMT2AMEN1L3MBTL1CYP1A2 | |
| SCHEMBL1806541 | 0.82 | OPRM1 (0.45) | ALDH1A1KMT2AMEN1L3MBTL1CYP1A2 | |
| SCHEMBL1805385 | 0.77 | AURKA (0.55) | ALDH1A1KMT2AMEN1L3MBTL1MAPK1 | |
| SCHEMBL1805296 | 0.76 | ALDH1A1 (0.45) | ALDH1A1KMT2AMEN1L3MBTL1CYP1A2 | |
| SCHEMBL13530264 | 0.75 | DCK (0.52) | ALDH1A1KMT2AMEN1L3MBTL1CYP1A2 | |
| SCHEMBL1806470 | 0.74 | MERTK (0.60) | ALDH1A1KMT2AMEN1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2493863-B1 | PHENOXY-SUBSTITUTED PYRIMIDINES AS OPIOID RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-02-25 | — | — | EP | disclosed |
| EP-2493863-B1 | PHENOXY-SUBSTITUTED PYRIMIDINES AS OPIOID RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-02-25 | — | — | EP | disclosed |
| US-8895573-B2 | Phenoxy-substituted pyrimidines as opioid receptor modulators | JANSSEN PHARMACEUTICA, NV (BE) | 2014-11-25 | — | — | US | disclosed |
| US-8895573-B2 | Phenoxy-substituted pyrimidines as opioid receptor modulators | JANSSEN PHARMACEUTICA, NV (BE) | 2014-11-25 | — | — | US | disclosed |
| US-8895573-B2 | Phenoxy-substituted pyrimidines as opioid receptor modulators | JANSSEN PHARMACEUTICA, NV (BE) | 2014-11-25 | — | — | US | disclosed |
| US-20140066422-A1 | PHENOXY-SUBSTITUTED PYRIMIDINES AS OPIOID RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA, NV (BE) | 2014-03-06 | — | — | US | disclosed |
| US-20140066422-A1 | PHENOXY-SUBSTITUTED PYRIMIDINES AS OPIOID RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA, NV (BE) | 2014-03-06 | — | — | US | disclosed |
| US-20140066422-A1 | PHENOXY-SUBSTITUTED PYRIMIDINES AS OPIOID RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA, NV (BE) | 2014-03-06 | — | — | US | disclosed |
| US-8394809-B2 | Phenoxy-substituted pyrimidines as opioid receptor modulators | JANSSEN PHARMACEUTICA, NV (BE) | 2013-03-12 | — | — | US | disclosed |
| US-8394809-B2 | Phenoxy-substituted pyrimidines as opioid receptor modulators | JANSSEN PHARMACEUTICA, NV (BE) | 2013-03-12 | — | — | US | disclosed |
| US-8394809-B2 | Phenoxy-substituted pyrimidines as opioid receptor modulators | JANSSEN PHARMACEUTICA, NV (BE) | 2013-03-12 | — | — | US | disclosed |
| EP-2493863-A1 | PHENOXY-SUBSTITUTED PYRIMIDINES AS OPIOID RECEPTOR MODULATORS | Janssen Pharmaceutica NV (BE) | 2012-09-05 | — | — | EP | disclosed |
| US-20110105455-A1 | PHENOXY-SUBSTITUTED PYRIMIDINES AS OPIOID RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA, NV (BE) | 2011-05-05 | — | — | US | disclosed |
| US-20110105455-A1 | PHENOXY-SUBSTITUTED PYRIMIDINES AS OPIOID RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA, NV (BE) | 2011-05-05 | — | — | US | disclosed |
| US-20110105455-A1 | PHENOXY-SUBSTITUTED PYRIMIDINES AS OPIOID RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA, NV (BE) | 2011-05-05 | — | — | US | disclosed |
| WO-2011053701-A1 | PHENOXY-SUBSTITUTED PYRIMIDINES AS OPIOID RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2011-05-05 | — | — | WO | disclosed |
| WO-2011053701-A1 | PHENOXY-SUBSTITUTED PYRIMIDINES AS OPIOID RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2011-05-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140066422-A1 | PHENOXY-SUBSTITUTED PYRIMIDINES AS OPIOID RECEPTOR MODULATORS | OPRK1, OPRL1, OPRM1 | ALDH1A1 590/4885KMT2A 1602/4885MEN1 4868/4885 |
| US-20110105455-A1 | PHENOXY-SUBSTITUTED PYRIMIDINES AS OPIOID RECEPTOR MODULATORS | OPRK1, OPRL1, OPRM1 | ALDH1A1 590/4885KMT2A 1602/4885MEN1 4868/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.