Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.59 |
| ▸ | LMNA | P02545 | 4/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | CTSD | P07339 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | MGAM | O43451 | 1/20 | 0.50 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | SI | P14410 | 1/20 | 0.50 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.50 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1802857 | 0.86 | CXCR3 (0.57) | MAPTLMNATSHRCTSDALDH1A1 | |
| SCHEMBL1800064 | 0.86 | CTSD (0.46) | MAPTLMNATSHRTDP1CTSD | |
| SCHEMBL1802569 | 0.84 | SMN1; SMN2 (0.50) | TDP1CTSDALDH1A1NPSR1GAA | |
| SCHEMBL1801571 | 0.81 | CTSD (0.45) | TSHRCTSDALDH1A1NPSR1KDM4E | |
| SCHEMBL1802357 | 0.81 | F2R (0.41) | MAPTLMNATSHRTDP1CTSD | |
| SCHEMBL1818686 | 0.80 | MAPT (0.59) | MAPTLMNATSHRTDP1CTSD | |
| SCHEMBL1386316 | 0.75 | BCHE (0.68) | MAPTLMNATSHRCTSDKDM4E | |
| Bromide SCHEMBL29537277 | 0.69 | MAPT (0.52) | MAPTLMNATSHRTDP1CTSD | |
| SCHEMBL1801438 | 0.69 | SMN1; SMN2 (0.49) | MAPTLMNATDP1CTSDALDH1A1 | |
| SCHEMBL1180378 | 0.67 | GAA (1.00) | ALDH1A1HTTMGAMAMY1AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951957-B2 | Substituted benzimidazoles and their use for inducing apoptosis | BASILEA PHARMACEUTICA AG (CH) | 2011-05-31 | — | — | US | claimed |