Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | ALPL | P05186 | 2/20 | 0.49 |
| ▸ | ALPG | P10696 | 2/20 | 0.49 |
| ▸ | ALPP | P05187 | 1/20 | 0.49 |
| ▸ | PLAA | Q9Y263 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | CA3 | P07451 | 2/20 | 0.46 |
| ▸ | CA4 | P22748 | 2/20 | 0.46 |
| ▸ | CA6 | P23280 | 2/20 | 0.46 |
| ▸ | CA5A | P35218 | 2/20 | 0.46 |
| ▸ | CA7 | P43166 | 2/20 | 0.46 |
| ▸ | CA9 | Q16790 | 2/20 | 0.46 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1801438 | 0.85 | SMN1; SMN2 (0.49) | SMN1; SMN2NPC1GAARAB9AALPL | |
| SCHEMBL1802857 | 0.84 | CXCR3 (0.57) | SMN1; SMN2NPC1GAARAB9ACTSD | |
| SCHEMBL1803118 | 0.84 | MAPT (0.59) | SMN1; SMN2GAARAB9ATDP1TP53 | |
| SCHEMBL1801571 | 0.81 | CTSD (0.45) | SMN1; SMN2ALPLALPGALPPPLAA | |
| SCHEMBL1800064 | 0.81 | CTSD (0.46) | SMN1; SMN2ALPLALPGALPPPLAA | |
| SCHEMBL1802357 | 0.81 | F2R (0.41) | SMN1; SMN2ALPLALPGALPPPLAA | |
| SCHEMBL5000985 | 0.80 | SMN1; SMN2 (0.53) | SMN1; SMN2NPC1GAARAB9AALPL | |
| SCHEMBL1385336 | 0.65 | ALDH1A1 (0.56) | SMN1; SMN2TP53NPSR1ALDH1A1THRB | |
| SCHEMBL14470429 | 0.64 | F2R (0.61) | SMN1; SMN2ALPLALPGALPPPLAA | |
| SCHEMBL1818686 | 0.63 | MAPT (0.59) | SMN1; SMN2GAARAB9ATDP1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951957-B2 | Substituted benzimidazoles and their use for inducing apoptosis | BASILEA PHARMACEUTICA AG (CH) | 2011-05-31 | — | — | US | claimed |