Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.59 |
| ▸ | LMNA | P02545 | 4/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.56 |
| ▸ | CTSD | P07339 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | MGAM | O43451 | 1/20 | 0.53 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | SI | P14410 | 1/20 | 0.53 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.53 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4996791 | 0.86 | CXCR3 (0.57) | MAPTLMNATSHRALDH1A1NPSR1 | |
| SCHEMBL5000985 | 0.84 | SMN1; SMN2 (0.53) | TSHRTDP1ALDH1A1NPSR1CTSD | |
| SCHEMBL5000979 | 0.83 | SMN1; SMN2 (0.45) | MAPTLMNATSHRTDP1NPSR1 | |
| SCHEMBL1803118 | 0.80 | MAPT (0.59) | MAPTLMNATSHRTDP1ALDH1A1 | |
| SCHEMBL1386316 | 0.73 | BCHE (0.68) | MAPTLMNATSHRCTSDKDM4E | |
| SCHEMBL1180378 | 0.69 | GAA (1.00) | ALDH1A1HTTMGAMAMY1AGAA | |
| Bromide SCHEMBL29537277 | 0.67 | MAPT (0.52) | MAPTLMNATSHRTDP1ALDH1A1 | |
| SCHEMBL1800064 | 0.67 | CTSD (0.46) | MAPTLMNATSHRTDP1ALDH1A1 | |
| SCHEMBL14470429 | 0.67 | F2R (0.61) | TDP1NPSR1CTSDHTTSMN1; SMN2 | |
| SCHEMBL11262638 | 0.66 | APEX1 (0.62) | MAPTLMNATSHRTDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080287681-A1 | Substituted Benzimidazoles and their Use for Inducing Apoptosis | EBERLE MARTIN | 2008-11-20 | — | — | US | claimed |
| US-7951957-B2 | Substituted benzimidazoles and their use for inducing apoptosis | BASILEA PHARMACEUTICA AG (CH) | 2011-05-31 | — | — | US | disclosed |
| US-20080287681-A1 | Substituted Benzimidazoles and their Use for Inducing Apoptosis | EBERLE MARTIN | 2008-11-20 | — | — | US | disclosed |
| US-7423157-B2 | Substituted benzimidazoles and their use for inducing apoptosis | BASILEA PHARMACEUTICA AG (CH) | 2008-09-09 | — | — | US | disclosed |
| US-20070167505-A1 | Substituted benzimidazoles and their use for inducing apoptosis | BASILEA PHARMACEUTICA AG | 2007-07-19 | — | — | US | disclosed |
| US-20070066670-A1 | Substituted benzimidazoles and their use for inducing apoptosis | BASILEA PHARMACEUTICA AG | 2007-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070167505-A1 | Substituted benzimidazoles and their use for inducing apoptosis | BAX, BCL2, BAD | MAPT 4687/4885LMNA 445/4885TSHR 1194/4885 |
| US-20070066670-A1 | Substituted benzimidazoles and their use for inducing apoptosis | BAX, BCL2, BAD | MAPT 4687/4885LMNA 445/4885TSHR 1194/4885 |
| US-20080287681-A1 | Substituted Benzimidazoles and their Use for Inducing Apoptosis | BAX, BCL2, BAD | MAPT 4687/4885LMNA 445/4885TSHR 1194/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.