Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSD | P07339 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.41 |
| ▸ | F2R | P25116 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CXCR3 | P49682 | 2/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.39 |
| ▸ | ALPP | P05187 | 1/20 | 0.39 |
| ▸ | ALPG | P10696 | 1/20 | 0.39 |
| ▸ | PLAA | Q9Y263 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1803118 | 0.86 | MAPT (0.59) | CTSDMAPTLMNATSHRTDP1 | |
| SCHEMBL1801571 | 0.85 | CTSD (0.45) | CTSDTSHRALDH1A1NPSR1F2R | |
| SCHEMBL1802357 | 0.85 | F2R (0.41) | CTSDMAPTLMNATSHRTDP1 | |
| SCHEMBL1802857 | 0.81 | CXCR3 (0.57) | CTSDMAPTLMNATSHRALDH1A1 | |
| SCHEMBL1802569 | 0.81 | SMN1; SMN2 (0.50) | CTSDTDP1ALDH1A1NPSR1F2R | |
| SCHEMBL5000979 | 0.68 | SMN1; SMN2 (0.45) | CTSDMAPTLMNATSHRTDP1 | |
| SCHEMBL1801438 | 0.68 | SMN1; SMN2 (0.49) | CTSDMAPTLMNATDP1ALDH1A1 | |
| SCHEMBL1818686 | 0.67 | MAPT (0.59) | CTSDMAPTLMNATSHRTDP1 | |
| SCHEMBL1491096 | 0.64 | POLB (0.47) | MAPTMEN1KMT2A | |
| SCHEMBL2581813 | 0.63 | KDM4E (0.68) | MAPTTSHRSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951957-B2 | Substituted benzimidazoles and their use for inducing apoptosis | BASILEA PHARMACEUTICA AG (CH) | 2011-05-31 | — | — | US | claimed |