Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.41 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.41 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 7/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21890845 | 0.89 | RPS6KA3 (0.40) | RPS6KA3RPS6KA2MAPTMAPK1TP53 | |
| SCHEMBL18058762 | 0.89 | HDAC8 (0.41) | RPS6KA3RPS6KA2MAPTMAPK1TP53 | |
| SCHEMBL18410384 | 0.86 | MAPT (0.41) | RPS6KA3RPS6KA2MAPTMAPK1TP53 | |
| SCHEMBL15731795 | 0.86 | PIK3R1 (0.39) | MAPTMAPK1TP53SMN1; SMN2MEN1 | |
| SCHEMBL20050092 | 0.84 | ALDH1A1 (0.42) | MAPTTP53SMN1; SMN2MEN1KMT2A | |
| SCHEMBL17576245 | 0.84 | AKR1C3 (0.44) | MAPTMAPK1TP53SMN1; SMN2MEN1 | |
| SCHEMBL1919863 | 0.84 | AKR1C3 (0.44) | MAPTTP53SMN1; SMN2MEN1KMT2A | |
| SCHEMBL6330031 | 0.84 | KMT2A (0.49) | MAPTMAPK1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL29483984 | 0.84 | RAD51 (0.51) | PTGS2MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL186752 | 0.84 | LMNA (0.51) | MAPTMAPK1SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017013079-A1 | DIMER IMPURITIES OF APIXABAN AND METHOD TO REMOVE THEM | F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2017-01-26 | — | — | WO | disclosed |
| EP-3064497-A1 | DIMER IMPURITIES OF APIXABAN AND METHOD TO REMOVE THEM | F.I.S.- Fabbrica Italiana Sintetici S.p.A. (IT) | 2016-09-07 | — | — | EP | disclosed |