Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.38 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21890845 | 0.86 | RPS6KA3 (0.40) | MAPTALDH1A1PKMNPC1RAB9A | |
| SCHEMBL18058762 | 0.86 | HDAC8 (0.41) | MAPTALDH1A1PKMNPC1RAB9A | |
| SCHEMBL18058760 | 0.86 | PTGS2 (0.41) | MAPTKMT2AMEN1TP53MAPK1 | |
| SCHEMBL17576245 | 0.82 | AKR1C3 (0.44) | MAPTALDH1A1KMT2APKMMEN1 | |
| SCHEMBL15731795 | 0.80 | PIK3R1 (0.39) | MAPTALDH1A1KMT2AMEN1NPC1 | |
| SCHEMBL6330031 | 0.79 | KMT2A (0.49) | MAPTALDH1A1KMT2AMEN1NPC1 | |
| SCHEMBL29483984 | 0.79 | RAD51 (0.51) | MAPTKMT2AMEN1TSHRSMN1; SMN2 | |
| SCHEMBL20050092 | 0.79 | ALDH1A1 (0.42) | MAPTALDH1A1KMT2APKMMEN1 | |
| SCHEMBL1919863 | 0.79 | AKR1C3 (0.44) | MAPTALDH1A1KMT2AMEN1NPC1 | |
| SCHEMBL186752 | 0.79 | LMNA (0.51) | MAPTALDH1A1KMT2APKMMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3280714-B1 | DIMER IMPURITIES OF APIXABAN AND METHOD TO REMOVE THEM | FIS FABBRICA ITALIANA SINTETICI SPA (IT) | 2019-02-06 | — | — | EP | disclosed |
| WO-2017013079-A1 | DIMER IMPURITIES OF APIXABAN AND METHOD TO REMOVE THEM | F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2017-01-26 | — | — | WO | disclosed |