Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.40 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18058760 | 0.89 | PTGS2 (0.41) | HDAC8HDAC6MAPTSMN1; SMN2RPS6KA3 | |
| SCHEMBL21890845 | 0.87 | RPS6KA3 (0.40) | MAPTSMN1; SMN2RPS6KA3RPS6KA2TDP1 | |
| SCHEMBL18410384 | 0.86 | MAPT (0.41) | MAPTSMN1; SMN2RPS6KA3RPS6KA2KDM4E | |
| SCHEMBL15731795 | 0.83 | PIK3R1 (0.39) | MAPTSMN1; SMN2TDP1KDM4EALDH1A1 | |
| SCHEMBL1919863 | 0.82 | AKR1C3 (0.44) | MAPTSMN1; SMN2ALDH1A1ATMNPC1 | |
| SCHEMBL20050092 | 0.82 | ALDH1A1 (0.42) | MAPTSMN1; SMN2TDP1KDM4EALDH1A1 | |
| SCHEMBL29483984 | 0.82 | RAD51 (0.51) | MAPTSMN1; SMN2TDP1TSHR | |
| SCHEMBL17576245 | 0.82 | AKR1C3 (0.44) | MAPTSMN1; SMN2TDP1KDM4EALDH1A1 | |
| SCHEMBL6330031 | 0.82 | KMT2A (0.49) | MAPTSMN1; SMN2TDP1KDM4EALDH1A1 | |
| SCHEMBL186752 | 0.82 | LMNA (0.51) | MAPTSMN1; SMN2TDP1ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017013079-A1 | DIMER IMPURITIES OF APIXABAN AND METHOD TO REMOVE THEM | F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2017-01-26 | — | — | WO | disclosed |
| EP-3064497-A1 | DIMER IMPURITIES OF APIXABAN AND METHOD TO REMOVE THEM | F.I.S.- Fabbrica Italiana Sintetici S.p.A. (IT) | 2016-09-07 | — | — | EP | disclosed |