Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | STAT3 | P40763 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | CCKBR | P32239 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL339362 | 0.79 | CXCL8 (0.46) | ALDH1A1SMN1; SMN2KMT2APOLBLMNA | |
| SCHEMBL341017 | 0.78 | KMT2A (0.45) | ALDH1A1SMN1; SMN2KMT2APOLBLMNA | |
| SCHEMBL5642336 | 0.76 | MDM2 (0.59) | TAAR1ALDH1A1MDM2SMN1; SMN2KMT2A | |
| SCHEMBL338541 | 0.76 | MAPT (0.43) | ALDH1A1SMN1; SMN2KMT2APOLBMEN1 | |
| SCHEMBL341491 | 0.74 | SOAT1 (0.46) | ALDH1A1SMN1; SMN2KMT2ALMNAMEN1 | |
| SCHEMBL18061112 | 0.74 | TAAR1 (0.51) | TAAR1ALDH1A1MDM2SMN1; SMN2KMT2A | |
| SCHEMBL341352 | 0.72 | LMNA (0.50) | ALDH1A1MDM2SMN1; SMN2KMT2APOLB | |
| SCHEMBL2393839 | 0.71 | PTGS2 (0.56) | SMN1; SMN2KMT2ALMNAMEN1 | |
| SCHEMBL305498 | 0.71 | TAAR1 (1.00) | TAAR1ALDH1A1MDM2SMN1; SMN2KMT2A | |
| Biphenyl SCHEMBL7876282 | 0.70 | PTGS2 (0.58) | KMT2APKMLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2776389-B1 | ARYL UREA DERIVATIVES AS N-FORMYL PEPTIDE RECEPTOR LIKE-1 (FPRL-1) RECEPTOR MODULATORS | ALLERGAN INC (US) | 2016-09-21 | — | — | EP | claimed |