Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.81 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | MGAM | O43451 | 1/20 | 0.46 |
| ▸ | SI | P14410 | 1/20 | 0.46 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.46 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL208141 | 0.90 | — | — | |
| SCHEMBL4650134 | 0.88 | CYP1A2 (0.61) | CYP1A2GAAMGAMSIMGAM2 | |
| Hydrochloric Acid SCHEMBL2656136 | 0.88 | CYP1A2 (0.95) | CYP1A2GAAMGAMSIMGAM2 | |
| Hydrochloric Acid SCHEMBL572907 | 0.88 | CYP1A2 (0.95) | CYP1A2GAAMGAMSIMGAM2 | |
| Water SCHEMBL28807419 | 0.88 | CYP1A2 (0.95) | CYP1A2GAAMGAMSIMGAM2 | |
| SCHEMBL1093065 | 0.84 | CYP1A2 (0.87) | CYP1A2GAAMGAMSIMGAM2 | |
| SCHEMBL2967294 | 0.82 | CYP1A2 (0.83) | CYP1A2GAAMGAMSIMGAM2 | |
| SCHEMBL7547097 | 0.82 | CYP1A2 (0.83) | CYP1A2GAAMGAMSIMGAM2 | |
| SCHEMBL1463911 | 0.82 | CYP1A2 (0.83) | CYP1A2GAAMGAMSIMGAM2 | |
| SCHEMBL3284074 | 0.82 | CYP1A2 (0.83) | CYP1A2GAAMGAMSIMGAM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11332478-B2 | Manufacture of 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol | H. LUNDBECK A/S (DK) | 2022-05-17 | — | — | US | disclosed |
| CN-107428776-B | Production of 4,5,6, 7-tetrahydroisoxazolo [5,4-c ] pyridin-3-ol | H.隆德贝克有限公司 | 2020-10-23 | — | — | CN | disclosed |
| US-20200223865-A1 | MANUFACTURE OF 4,5,6,7-TETRAHYDROISOXAZOLO[5,4-C]PYRIDIN-3-OL | H. LUNDBECK A/S (DK) | 2020-07-16 | — | — | US | disclosed |
| US-10626123-B2 | Manufacture of 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol | H. LUNDBECK A/S (DK) | 2020-04-21 | — | — | US | disclosed |
| EP-3274331-B1 | MANUFACTURE OF 4,5,6,7-TETRAHYDROISOZAXOLO[5,4-C]PYRIDIN-3-OL | H LUNDBECK AS (DK) | 2020-02-26 | — | — | EP | disclosed |
| US-20180065984-A1 | Manufacture of 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol | H. LUNDBECK A/S (DK) | 2018-03-08 | — | — | US | disclosed |
| EP-3274331-A1 | MANUFACTURE OF 4,5,6,7-TETRAHYDROISOZAXOLO[5,4-C]PYRIDIN-3-OL | H. Lundbeck A/S (DK) | 2018-01-31 | — | — | EP | disclosed |
| CN-107428776-A | Production of 4,5,6, 7-tetrahydroisoxazolo [5,4-c ] pyridin-3-ol | H.隆德贝克有限公司 | 2017-12-01 | — | — | CN | disclosed |
| WO-2016150953-A1 | MANUFACTURE OF 4,5,6,7-TETRAHYDROISOZAXOLO[5,4-C]PYRIDIN-3-OL | H. LUNDBECK A/S (DK) | 2016-09-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11332478-B2 | Manufacture of 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol | GABRP, GABRD, GABRA5 | CYP1A2 55/4885GAA 4307/4885MGAM 4684/4885 |
| US-10626123-B2 | Manufacture of 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol | GABRP, GABRA5, GABRD | CYP1A2 53/4885GAA 4320/4885MGAM 4694/4885 |
| US-20200223865-A1 | MANUFACTURE OF 4,5,6,7-TETRAHYDROISOXAZOLO[5,4-C]PYRIDIN-3-OL | GABRP, GABRD, GABRA5 | CYP1A2 55/4885GAA 4307/4885MGAM 4684/4885 |
| US-20180065984-A1 | Manufacture of 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol | GABRP, GABRA5, GABRD | CYP1A2 53/4885GAA 4320/4885MGAM 4694/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.