Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 4/20 | 1.00 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.98 |
| ▸ | P4HB | P07237 | 5/20 | 0.98 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.98 |
| ▸ | GAA | P10253 | 4/20 | 0.98 |
| ▸ | POLB | P06746 | 3/20 | 0.98 |
| ▸ | MAPT | P10636 | 3/20 | 0.98 |
| ▸ | CA12 | O43570 | 3/20 | 0.98 |
| ▸ | CA2 | P00918 | 3/20 | 0.98 |
| ▸ | CA4 | P22748 | 3/20 | 0.98 |
| ▸ | CA7 | P43166 | 3/20 | 0.98 |
| ▸ | ALPL | P05186 | 2/20 | 0.98 |
| ▸ | ALPI | P09923 | 2/20 | 0.98 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.98 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.98 |
| ▸ | KDM1A | O60341 | 1/20 | 0.98 |
| ▸ | SLCO2B1 | O94956 | 1/20 | 0.98 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.98 |
| ▸ | PKM | P14618 | 1/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Avicularin SCHEMBL1252098 | 1.00 | AKR1B1 (1.00) | AKR1B1L3MBTL1KDM4EP4HBEPHX2 | |
| Avicularin SCHEMBL151758 | 1.00 | AKR1B1 (1.00) | AKR1B1L3MBTL1KDM4EP4HBEPHX2 | |
| Avicularin SCHEMBL30637540 | 1.00 | AKR1B1 (1.00) | AKR1B1L3MBTL1KDM4EP4HBEPHX2 | |
| Avicularin SCHEMBL29505880 | 1.00 | AKR1B1 (1.00) | AKR1B1L3MBTL1KDM4EP4HBEPHX2 | |
| Avicularin SCHEMBL119816 | 1.00 | AKR1B1 (1.00) | AKR1B1L3MBTL1KDM4EP4HBEPHX2 | |
| Avicularin SCHEMBL13182845 | 1.00 | AKR1B1 (1.00) | AKR1B1L3MBTL1KDM4EP4HBEPHX2 | |
| Avicularin SCHEMBL25174412 | 1.00 | AKR1B1 (1.00) | AKR1B1L3MBTL1KDM4EP4HBEPHX2 | |
| Avicularin SCHEMBL1626867 | 1.00 | AKR1B1 (1.00) | AKR1B1L3MBTL1KDM4EP4HBEPHX2 | |
| Avicularin SCHEMBL30185786 | 1.00 | AKR1B1 (1.00) | AKR1B1L3MBTL1KDM4EP4HBEPHX2 | |
| Isoquercetin SCHEMBL12710506 | 0.99 | P4HB (1.00) | AKR1B1L3MBTL1KDM4EP4HBEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117837498-A | Method for improving and regulating synthesis of flavonoids in saussurea involucrata leaves | 石河子大学 | 2024-04-09 | — | — | CN | disclosed |
| CN-114796341-A | Chinese magnoliavine fruit plant medicine for treating lithangiuria | 山东第一医科大学附属省立医院(山东省立医院) | 2022-07-29 | — | — | CN | disclosed |
| CN-108619245-B | New application of guava leaves and total flavonoids in guava leaves | 天津市医药科学研究所 | 2021-08-27 | — | — | CN | disclosed |
| US-20200297692-A1 | SGLT-2 INHIBITORS FOR TREATING METABOLIC DISORDERS IN PATIENTS WITH RENAL IMPAIRMENT OR CHRONIC KIDNEY DISEASE | MERCK SHARP & DOHME CORP. (US) | 2020-09-24 | — | — | US | disclosed |
| US-10709684-B2 | SGLT-2 inhibitors for treating metabolic disorders in patients with renal impairment or chronic kidney disease | MERCK SHARP & DOHME CORP. (US) | 2020-07-14 | — | — | US | disclosed |
| US-20200054598-A1 | SGLT-2 INHIBITORS FOR TREATING METABOLIC DISORDERS IN PATIENTS WITH RENAL IMPAIRMENT OR CHRONIC KIDNEY DISEASE | MERCK SHARP & DOHME CORP. (US) | 2020-02-20 | — | — | US | disclosed |
| US-10500186-B2 | SGLT-2 inhibitors for treating metabolic disorders in patients with renal impairment or chronic kidney disease | MERCK SHARP & DOHME CORP. (US) | 2019-12-10 | — | — | US | disclosed |
| US-20190142793-A1 | SGLT-2 INHIBITORS FOR TREATING METABOLIC DISORDERS IN PATIENTS WITH RENAL IMPAIRMENT OR CHRONIC KIDNEY DISEASE | MERCK SHARP & DOHME CORP. (US) | 2019-05-16 | — | — | US | disclosed |
| US-10285973-B2 | SGLT-2 inhibitors for treating metabolic disorders in patients with renal impairment or chronic kidney disease | MERCK SHARP & DOHME CORP. (US) | 2019-05-14 | — | — | US | disclosed |
| US-20170304262-A1 | SGLT-2 INHIBITORS FOR TREATING METABOLIC DISORDERS IN PATIENTS WITH RENAL IMPAIRMENT OR CHRONIC KIDNEY DISEASE | MERCK SHARP & DOHME LLC | 2017-10-26 | — | — | US | disclosed |
| WO-2010023594-A1 | DIOXA-BICYCLO[3.2.1.]OCTANE-2,3,4-TRIOL DERIVATIVES | PFIZER INC. (US) | 2010-03-04 | — | — | WO | disclosed |
| US-20100056618-A1 | DIOXA-BICYCLO[3.2.1]OCTANE-2,3,4-TRIOL DERIVATIVES | PFIZER INC | 2010-03-04 | — | — | US | disclosed |
| US-20070292539-A1 | Anti-inflammatory cranberry flavonol extract preparations | VORSA NICHOLI | 2007-12-20 | — | — | US | disclosed |
| US-20070292539-A1 | Anti-inflammatory cranberry flavonol extract preparations | VORSA NICHOLI | 2007-12-20 | — | — | US | disclosed |
| US-20070292539-A1 | Anti-inflammatory cranberry flavonol extract preparations | VORSA NICHOLI | 2007-12-20 | — | — | US | disclosed |
| US-7270837-B2 | free of anthocyanins and proanthocyanidins; treatment of inflammatory disorders, particularly irritation of the urinary tract due to both bacterial and non-bacterial causes | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2007-09-18 | — | — | US | disclosed |
| US-7270837-B2 | free of anthocyanins and proanthocyanidins; treatment of inflammatory disorders, particularly irritation of the urinary tract due to both bacterial and non-bacterial causes | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2007-09-18 | — | — | US | disclosed |
| US-7270837-B2 | free of anthocyanins and proanthocyanidins; treatment of inflammatory disorders, particularly irritation of the urinary tract due to both bacterial and non-bacterial causes | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2007-09-18 | — | — | US | disclosed |
| US-20060088610-A1 | Anti-inflammatory cranberry flavonol extract preparations | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | 2006-04-27 | — | — | US | disclosed |
| US-20060088610-A1 | Anti-inflammatory cranberry flavonol extract preparations | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | 2006-04-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056618-A1 | DIOXA-BICYCLO[3.2.1]OCTANE-2,3,4-TRIOL DERIVATIVES | SLC5A2, SLC5A1, SLC2A2 | AKR1B1 195/4885L3MBTL1 3813/4885KDM4E 3890/4885 |
| US-10285973-B2 | SGLT-2 inhibitors for treating metabolic disorders in patients with renal impairment or chronic kidney disease | SLC5A1, SLC5A2, SLC2A1 | AKR1B1 946/4885L3MBTL1 1499/4885KDM4E 1229/4885 |
| US-10500186-B2 | SGLT-2 inhibitors for treating metabolic disorders in patients with renal impairment or chronic kidney disease | SLC5A1, SLC5A2, SLC2A1 | AKR1B1 946/4885L3MBTL1 1499/4885KDM4E 1229/4885 |
| US-20200297692-A1 | SGLT-2 INHIBITORS FOR TREATING METABOLIC DISORDERS IN PATIENTS WITH RENAL IMPAIRMENT OR CHRONIC KIDNEY DISEASE | SLC5A1, SLC5A2, SLC2A1 | AKR1B1 946/4885L3MBTL1 1499/4885KDM4E 1229/4885 |
| US-20070292539-A1 | Anti-inflammatory cranberry flavonol extract preparations | LGALS3, FUT6, GALNT6 | AKR1B1 2465/4885L3MBTL1 3211/4885KDM4E 714/4885 |
| US-20200054598-A1 | SGLT-2 INHIBITORS FOR TREATING METABOLIC DISORDERS IN PATIENTS WITH RENAL IMPAIRMENT OR CHRONIC KIDNEY DISEASE | SLC5A1, SLC5A2, SLC2A1 | AKR1B1 946/4885L3MBTL1 1499/4885KDM4E 1229/4885 |
| US-20060088610-A1 | Anti-inflammatory cranberry flavonol extract preparations | LGALS3, FUT6, GALNT6 | AKR1B1 2465/4885L3MBTL1 3211/4885KDM4E 714/4885 |
| US-10709684-B2 | SGLT-2 inhibitors for treating metabolic disorders in patients with renal impairment or chronic kidney disease | SLC5A1, SLC5A2, SLC2A1 | AKR1B1 946/4885L3MBTL1 1499/4885KDM4E 1229/4885 |
| US-20170304262-A1 | SGLT-2 INHIBITORS FOR TREATING METABOLIC DISORDERS IN PATIENTS WITH RENAL IMPAIRMENT OR CHRONIC KIDNEY DISEASE | SLC5A1, SLC5A2, SLC2A1 | AKR1B1 946/4885L3MBTL1 1499/4885KDM4E 1229/4885 |
| US-20190142793-A1 | SGLT-2 INHIBITORS FOR TREATING METABOLIC DISORDERS IN PATIENTS WITH RENAL IMPAIRMENT OR CHRONIC KIDNEY DISEASE | SLC5A1, SLC5A2, SLC2A1 | AKR1B1 923/4885L3MBTL1 1546/4885KDM4E 1227/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.