Avicularin

Avicularin

SCHEMBL151758

O=c1c(O[C@@H]2O[C@@H](CO)[C@H](O)[C@H]2O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AKR1B1 P15121 4/20 1.00
L3MBTL1 Q9Y468 2/20 1.00
KDM4E B2RXH2 5/20 0.98
P4HB P07237 5/20 0.98
EPHX2 P34913 5/20 0.98
GAA P10253 4/20 0.98
POLB P06746 3/20 0.98
MAPT P10636 3/20 0.98
CA12 O43570 3/20 0.98
CA2 P00918 3/20 0.98
CA4 P22748 3/20 0.98
CA7 P43166 3/20 0.98
ALPL P05186 2/20 0.98
ALPI P09923 2/20 0.98
ADRA2C P18825 1/20 0.98
NOX4 Q9NPH5 1/20 0.98
KDM1A O60341 1/20 0.98
SLCO2B1 O94956 1/20 0.98
HMGB1 P09429 1/20 0.98
PKM P14618 1/20 0.98

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Avicularin SCHEMBL1252098 1.00 AKR1B1 (1.00) AKR1B1L3MBTL1KDM4EP4HBEPHX2
Avicularin SCHEMBL30637540 1.00 AKR1B1 (1.00) AKR1B1L3MBTL1KDM4EP4HBEPHX2
Avicularin SCHEMBL29505880 1.00 AKR1B1 (1.00) AKR1B1L3MBTL1KDM4EP4HBEPHX2
Avicularin SCHEMBL119816 1.00 AKR1B1 (1.00) AKR1B1L3MBTL1KDM4EP4HBEPHX2
Avicularin SCHEMBL13182845 1.00 AKR1B1 (1.00) AKR1B1L3MBTL1KDM4EP4HBEPHX2
Avicularin SCHEMBL25174412 1.00 AKR1B1 (1.00) AKR1B1L3MBTL1KDM4EP4HBEPHX2
Avicularin SCHEMBL1626867 1.00 AKR1B1 (1.00) AKR1B1L3MBTL1KDM4EP4HBEPHX2
Avicularin SCHEMBL30185786 1.00 AKR1B1 (1.00) AKR1B1L3MBTL1KDM4EP4HBEPHX2
Avicularin SCHEMBL181203 1.00 AKR1B1 (1.00) AKR1B1L3MBTL1KDM4EP4HBEPHX2
Isoquercetin SCHEMBL12710506 0.99 P4HB (1.00) AKR1B1L3MBTL1KDM4EP4HBEPHX2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 620 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3780974-B1 GUAVA EXTRACT PM INT AG (LU) 2025-11-12 EP claimed
US-20240350574-A1 PHENOLIC PHYTOCHEMICALS FOR BONE METASTASIS OF CANCER NDSU RESEARCH FOUNDATION 2024-10-24 US claimed
US-20240325484-A1 COMPOSITION COMPRISING HORSE CHESTNUT EXTRACT ANGIOLAB, INC. (KR) 2024-10-03 US claimed
EP-4395802-A1 COMPOSITION COMPRISING HORSE CHESTNUT EXTRACT ANGIOLAB., INC. (KR) 2024-07-10 EP claimed
CN-117860794-A Processing method of mistletoe and quality detection method of processed product thereof 山西中医药大学 2024-04-12 CN claimed
CN-113873429-B Underground tunnel-oriented ridge regression two-dimensional positioning method and system 国网江苏省电力有限公司电力科学研究院 2024-03-26 CN claimed
WO-2023219526-A1 MULTITARGET ANTIVIRAL DIETARY SUPPLEMENT PROKIN MILAN (RS) 2023-11-16 WO claimed
CN-116966195-A Compound, composition and application thereof in preparation of medicines with effects of preventing and/or treating cardiomyopathy 海南医学院第一附属医院 2023-10-31 CN claimed
CN-115969867-A Application of avicularin in preparation of medicine/health-care product for preventing and treating osteoporosis 张家港市中医医院 2023-04-18 CN claimed
CN-113552242-B Method for constructing Chinese rose fingerprint, detection method and content determination method 广东一方制药有限公司 2023-04-07 CN claimed
US-20030105031-A1 Methods for the treatment of skin disorders QUIGLEY CORPORATION, THE 2003-06-05 US claimed
US-20030105027-A1 Nutritional supplements and methods for prevention, reduction and treatment of radiation injury QUIGLEY CORPORATION, THE 2003-06-05 US claimed
WO-2003039452-A2 NUTRITIONAL SUPPLEMENTS AND METHODS FOR PREVENTION, REDUCTION AND TREATMENT OF RADIATION INJURY THE QUIGLEY CORPORATION (US) 2003-05-15 WO claimed
US-6555573-B2 Comprising a cold compounded mixture of a compound that promotes synthesis of nerve growth factor, an aldose reductase inhibitor, antioxidant and carrier; side effect reduction; partial recovery of neurological function in some cases THE QUIGLEY CORPORATION 2003-04-29 US claimed
CN-1383381-A Therpauetic agent of osteoporisis comprising active ingredient of quercetin derivatives KOREA INST ORIENTAL MEDICINE (KR) 2002-12-04 CN claimed
US-20020165207-A1 Compositions and methods for the treatment of diabetic neuropathy QUIGLEY CORPORATION, THE 2002-11-07 US claimed
US-20020115618-A1 Method and composition for the topical treatment of diabetic neuropathy QUIGLEY CORPORATION, THE 2002-08-22 US claimed
WO-2002049575-A2 METHOD AND COMPOSITION FOR THE TREATMENT OF DIABETIC NEUROPATHY THE QUIGLEY CORPORATION (US) 2002-06-27 WO claimed
US-20020054924-A1 Novel compositions derived from cranberry and grapefruit and therapeutic uses therefor LEAHY MARGARET M (US) 2002-05-09 US claimed
WO-2001080870-A2 COMPOSITIONS DERIVED FROM CRANBERRY AND GRAPEFRUIT AND THERAPEUTIC USES THEREFOR OCEAN SPRAY CRANBERRIES, INC. (US) 2001-11-01 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030105027-A1 Nutritional supplements and methods for prevention, reduction and treatment of radiation injury FOXO3, NQO1, FOXO1 AKR1B1 834/4885L3MBTL1 4004/4885KDM4E 3889/4885
US-20030105031-A1 Methods for the treatment of skin disorders TYR, CUTA, NFATC1 AKR1B1 462/4885L3MBTL1 4806/4885KDM4E 871/4885
US-20240325484-A1 COMPOSITION COMPRISING HORSE CHESTNUT EXTRACT PRUNE1, HDLBP, CROCC AKR1B1 3109/4885L3MBTL1 4005/4885KDM4E 1412/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.