Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | PLK1 | P53350 | 3/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25567670 | 0.82 | HDAC6 (0.60) | HDAC6HDAC1HDAC8HDAC2KDM4E | |
| SCHEMBL7981473 | 0.79 | CES2 (0.56) | HDAC6HDAC1GAAHDAC8HDAC2 | |
| SCHEMBL1004064 | 0.78 | HDAC6 (0.70) | HDAC6HDAC1GAAHDAC8HDAC2 | |
| SCHEMBL22168037 | 0.78 | CA5A (0.43) | HDAC6HDAC1ALDH1A1CES2CES1 | |
| SCHEMBL14059749 | 0.77 | KDM4E (0.52) | GAACA2TSHRALDH1A1KDM4E | |
| SCHEMBL20017813 | 0.77 | PLK1 (0.46) | HDAC6HDAC1HDAC8HDAC2HPGD | |
| SCHEMBL21783935 | 0.76 | HDAC6 (0.68) | HDAC6HDAC1GAAHDAC8HDAC2 | |
| SCHEMBL1813635 | 0.75 | LMNA (0.44) | CA2HPGDTSHRHTTSMN1; SMN2 | |
| SCHEMBL28541372 | 0.75 | HPGD (0.47) | HPGDSMN1; SMN2NPC1RAB9A | |
| SCHEMBL38657509 | 0.74 | HDAC1 (0.47) | HDAC6HDAC1GAAHDAC8HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 74 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12503468-B2 | Heterocyclic compound, intermediate, preparation method therefor and application thereof | WUHAN LL SCIENCE AND TECHNOLOGY DEVELOPMENT CO., LTD. (CN) | 2025-12-23 | — | — | US | disclosed |
| CN-113272301-B | Heterocyclic compound, intermediate, preparation method and application thereof | 武汉朗来科技发展有限公司 | 2024-04-26 | — | — | CN | disclosed |
| CN-112409331-B | Heterocyclic derivative inhibitor, preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2024-02-20 | — | — | CN | disclosed |
| US-20240034729-A9 | HETEROCYCLIC COMPOUND, INTERMEDIATE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | WUHAN LL SCIENCE AND TECHNOLOGY DEVELOPMENT CO., LTD. (CN) | 2024-02-01 | — | — | US | disclosed |
| US-20230406851-A1 | IMIDAZOPYRIDINE COMPOUNDS AND USES THEREOF | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.3) LIMITED (GB) | 2023-12-21 | — | — | US | disclosed |
| US-20230250095-A1 | BENZIMIDAZOLE DERIVATIVES, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | TUOJIE BIOTECH(SHANGHAI) CO., LTD. (CN) | 2023-08-10 | — | — | US | disclosed |
| US-20230250095-A1 | BENZIMIDAZOLE DERIVATIVES, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | TUOJIE BIOTECH(SHANGHAI) CO., LTD. (CN) | 2023-08-10 | — | — | US | disclosed |
| US-20230250095-A1 | BENZIMIDAZOLE DERIVATIVES, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | TUOJIE BIOTECH(SHANGHAI) CO., LTD. (CN) | 2023-08-10 | — | — | US | disclosed |
| EP-4198034-A1 | BENZIMIDAZOLE DERIVATIVES, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | Tuojie Biotech (Shanghai) Co., Ltd. (CN) | 2023-06-21 | — | — | EP | disclosed |
| EP-4198034-A1 | BENZIMIDAZOLE DERIVATIVES, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | Tuojie Biotech (Shanghai) Co., Ltd. (CN) | 2023-06-21 | — | — | EP | disclosed |
| EP-2501697-B1 | BENZOIMIDAZOLE COMPOUNDS AND USES THEREOF | NEOMED INST (CA) | 2013-10-23 | — | — | EP | disclosed |
| EP-2501697-B1 | BENZOIMIDAZOLE COMPOUNDS AND USES THEREOF | NEOMED INST (CA) | 2013-10-23 | — | — | EP | disclosed |
| US-8530467-B2 | Benzoimidazole compounds and uses thereof | NEOMED INSTITUTE (CA) | 2013-09-10 | — | — | US | disclosed |
| US-8530467-B2 | Benzoimidazole compounds and uses thereof | NEOMED INSTITUTE (CA) | 2013-09-10 | — | — | US | disclosed |
| WO-2012158117-A1 | COMBINATION THERAPIES FOR TREATING PAIN | ASTRAZENECA AB (SE) | 2012-11-22 | — | — | WO | disclosed |
| WO-2012158117-A1 | COMBINATION THERAPIES FOR TREATING PAIN | ASTRAZENECA AB (SE) | 2012-11-22 | — | — | WO | disclosed |
| US-20120289504-A1 | Benzoimidazole Compounds and Uses Thereof | ASTRAZENECA AB (SE) | 2012-11-15 | — | — | US | disclosed |
| US-20120289504-A1 | Benzoimidazole Compounds and Uses Thereof | ASTRAZENECA AB (SE) | 2012-11-15 | — | — | US | disclosed |
| EP-2501697-A1 | BENZOIMIDAZOLE COMPOUNDS AND USES THEREOF | AstraZeneca AB (SE) | 2012-09-26 | — | — | EP | disclosed |
| WO-2011062550-A1 | BENZOIMIDAZOLE COMPOUNDS AND USES THEREOF | ASTRAZENECA AB (SE) | 2011-05-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230406851-A1 | IMIDAZOPYRIDINE COMPOUNDS AND USES THEREOF | NISCH, ABL1, PAICS | HDAC6 267/4885HDAC1 1311/4885GAA 558/4885 |
| US-20230250095-A1 | BENZIMIDAZOLE DERIVATIVES, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | P2RX7, P2RX3, P2RX5 | HDAC6 2396/4885HDAC1 2215/4885GAA 676/4885 |
| US-12503468-B2 | Heterocyclic compound, intermediate, preparation method therefor and application thereof | P2RX3, P2RX7, P2RX4 | HDAC6 3155/4885HDAC1 3602/4885GAA 3374/4885 |
| US-20120289504-A1 | Benzoimidazole Compounds and Uses Thereof | TPMT, BRD4, CYP3A4 | HDAC6 9/4885HDAC1 138/4885GAA 198/4885 |
| US-20240034729-A9 | HETEROCYCLIC COMPOUND, INTERMEDIATE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | P2RX3, P2RX7, P2RX4 | HDAC6 3155/4885HDAC1 3602/4885GAA 3374/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.