Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | GAA | P10253 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | KDM1A | O60341 | 3/20 | 0.37 |
| ▸ | CNR2 | P34972 | 2/20 | 0.35 |
| ▸ | NCF1 | P14598 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NQO2 | P16083 | 2/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | NSD2 | O96028 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4756517 | 0.98 | MAPT (0.39) | MAPTGAAKDM4EKDM1ACNR2 | |
| Hydrochloric Acid SCHEMBL3633973 | 0.82 | ALDH1A1 (0.37) | MAPTGAAKDM4EKDM1ACNR2 | |
| SCHEMBL9500423 | 0.80 | ALDH1A1 (0.38) | MAPTGAAKDM4EKDM1ACNR2 | |
| SCHEMBL5338489 | 0.75 | ALDH1A1 (0.34) | MAPTKDM4EALDH1A1POLBRAB9A | |
| Hydrochloric Acid SCHEMBL740017 | 0.74 | MAPT (0.53) | MAPTGAAKDM4EALDH1A1POLB | |
| Hydrochloric Acid SCHEMBL31542018 | 0.74 | MAPT (0.53) | MAPTGAAKDM4EALDH1A1POLB | |
| Hydrochloric Acid SCHEMBL8028506 | 0.74 | ALDH1A1 (0.39) | MAPTKDM4EALDH1A1POLBTDP1 | |
| SCHEMBL28661274 | 0.74 | MAPT (0.52) | MAPTGAAKDM4EKDM1ACNR2 | |
| SCHEMBL3360974 | 0.74 | MAPT (0.42) | MAPTKDM4EKDM1ANCF1ALDH1A1 | |
| SCHEMBL13386271 | 0.73 | RAB9A (0.38) | MAPTGAAKDM4EALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 72 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118073728-A | Photoelectrochemical energy storage battery driven by silicon electrode and application thereof | 中国科学院大连化学物理研究所 | 2024-05-24 | — | — | CN | claimed |
| CN-116687936-A | New application of phenothiazines or compounds with similar structures in pharmacy | 广州威溶特医药科技有限公司 | 2023-09-05 | — | — | CN | claimed |
| CN-112426521-B | New application of phenothiazines or compounds with similar structures in pharmacy | 广州威溶特医药科技有限公司 | 2023-08-01 | — | — | CN | claimed |
| CN-116410155-A | Method for preparing 3, 7-bis (dimethylamino) phenothiazin-5-ium iodide | 普如制药生命解决方案公司 | 2023-07-11 | — | — | CN | claimed |
| CN-110382472-B | Method for preparing 3, 7-bis (dimethylamino) phenothiazin-5-ium iodide | 普如制药生命解决方案公司 | 2023-05-09 | — | — | CN | claimed |
| CN-114555091-A | Formula product for preventing and/or treating peripheral neuropathy and related diseases thereof | 罗颍诗 | 2022-05-27 | — | — | CN | claimed |
| CN-113777881-A | Solder resist resin composition, solder resist structure, dry film, and printed wiring board | 韩国太阳油墨有限公司 | 2021-12-10 | — | — | CN | claimed |
| CN-112426521-A | New application of phenothiazines or compounds with similar structures in pharmacy | 广州威溶特医药科技有限公司 | 2021-03-02 | — | — | CN | claimed |
| CN-111358765-A | Polymer albumin nanosphere and preparation method and application thereof, drug-loaded polymer albumin nanosphere and preparation method and application thereof | 深圳先进技术研究院 | 2020-07-03 | — | — | CN | claimed |
| US-7939340-B2 | Hydroxyl radical detection | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2011-05-10 | — | — | US | claimed |
| CN-118073728-A | Photoelectrochemical energy storage battery driven by silicon electrode and application thereof | 中国科学院大连化学物理研究所 | 2024-05-24 | — | — | CN | disclosed |
| CN-117447421-A | Synthesis method of 3, 7-bis- (dimethylamino) -phenothiazine | 上海沃凯生物技术有限公司 | 2024-01-26 | — | — | CN | disclosed |
| CN-117433867-A | Fluorescent staining solution for vaginal microorganisms and method for detecting vaginal microorganisms | 深圳联合医学科技有限公司 | 2024-01-23 | — | — | CN | disclosed |
| CN-117209450-A | Chemical synthesis method of diaminophenothiazinium compound including methyl sulfonium chloride (MTC) | 维斯塔实验室有限公司 | 2023-12-12 | — | — | CN | disclosed |
| CN-110092764-B | Chemical synthesis method of diaminophenothiazinium compound including methyl sulfonium chloride (MTC) | 维斯塔实验室有限公司 | 2023-09-15 | — | — | CN | disclosed |
| WO-2000021513-A2 | METHODS FOR TREATING MULTIPLE SCLEROSIS | SHANKAR L SAI LATHA (US) | 2000-04-20 | — | — | WO | disclosed |
| US-5909114-A | Coulometric analysis method and a device therefor | NAKANO VINEGAR CO., LTD. (JP) | 1999-06-01 | — | — | US | disclosed |
| US-5726565-A | FOR QUANTITATIVE DETERMINATION OF A SAMPLE SUBSTANCE | NAKANO VINEGAR CO., LTD. (JP) | 1998-03-10 | — | — | US | disclosed |
| EP-0600607-A2 | Coulometric analysis method and a device therefor | NAKANO VINEGAR CO., LTD. (JP) | 1994-06-08 | — | — | EP | disclosed |
| US-4472253-A | Process for the preparation of an N-substituted 3-O-alkyl-14-hydroxynormorphinone derivative | THE FLORIDA BOARD OF REGENTS ON BEHALF OF THE FLORIDA STATE UNIVERSITY (US) | 1984-09-18 | — | — | US | disclosed |