SCHEMBL18130090

SCHEMBL18130090

[N-]=[N+]=Nc1ccc(/C=C/c2ccc(O)c(O)c2)cc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ LCK P06239 4/20 0.61
▸ NQO2 P16083 4/20 0.58
▸ POLB P06746 4/20 0.52
▸ ALDH1A1 P00352 4/20 0.52
▸ BLM P54132 3/20 0.52
▸ L3MBTL1 Q9Y468 3/20 0.52
▸ HSD17B10 Q99714 3/20 0.52
▸ KDM4E B2RXH2 3/20 0.52
▸ MEN1 O00255 3/20 0.52
▸ LMNA P02545 3/20 0.52
▸ MAPT P10636 3/20 0.52
▸ HPGD P15428 3/20 0.52
▸ KMT2A Q03164 3/20 0.52
▸ CYP3A4 P08684 3/20 0.52
▸ ALOX5 P09917 3/20 0.52
▸ ALOX12 P18054 2/20 0.52
▸ GFER P55789 2/20 0.52
▸ TP53 P04637 2/20 0.52
▸ ALOX15 P16050 2/20 0.52
▸ SMN1; SMN2 Q16637 2/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18130091 1.00 LCK (0.61) LCKNQO2POLBALDH1A1BLM
SCHEMBL18130069 0.89 PTGS2 (0.47) LCKNQO2POLBALDH1A1BLM
SCHEMBL18130068 0.89 PTGS2 (0.47) LCKNQO2POLBALDH1A1BLM
SCHEMBL13882617 0.84 CA1 (0.47) TP53CA12CA1CA2CA4
SCHEMBL23854165 0.84 CA1 (0.47) TP53CA12CA1CA2CA4
SCHEMBL18130123 0.83 NQO2 (0.48) LCKNQO2POLBALDH1A1BLM
SCHEMBL18130122 0.83 NQO2 (0.48) LCKNQO2POLBALDH1A1BLM
SCHEMBL17826850 0.82 PTGS1 (0.57) LCKNQO2POLBALDH1A1BLM
SCHEMBL18130124 0.82 PTGS1 (0.57) LCKNQO2POLBALDH1A1BLM
SCHEMBL10335571 0.80 LCK (0.94) LCKNQO2POLBALDH1A1BLM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3280402-B1 TOLAN COMPOUNDS FOR PROMOTING WOUND HEALING BIOMENDICS LLC (US) 2024-06-05 — — EP disclosed
US-11786481-B2 Formulation and process for modulating wound healing BioMendics, LLC (US) 2023-10-17 — — US disclosed
US-20210228501-A1 Formulation and Process for Modulating Wound Healing BioMendics, LLC (US) 2021-07-29 — — US disclosed
US-10426742-B2 Formulation and process for modulating wound healing BioMendics, LLC (US) 2019-10-01 — — US disclosed
US-20190022029-A1 Formulation and Process for Modulating Wound Healing BioMendics, LLC (US) 2019-01-24 — — US disclosed
US-20160296477-A1 Formulation and Process for Modulating Wound Healing BioMendics, LLC (US) 2016-10-13 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11786481-B2 Formulation and process for modulating wound healing SQSTM1, ATG7, TFEB LCK 4119/4885NQO2 3151/4885POLB 3227/4885
US-20160296477-A1 Formulation and Process for Modulating Wound Healing SQSTM1, ATG7, TFEB LCK 4216/4885NQO2 3288/4885POLB 3314/4885
US-20210228501-A1 Formulation and Process for Modulating Wound Healing ATG7, SQSTM1, ATF4 LCK 4007/4885NQO2 3338/4885POLB 3317/4885
US-10426742-B2 Formulation and process for modulating wound healing SQSTM1, ATG7, TFEB LCK 4119/4885NQO2 3151/4885POLB 3227/4885
US-20190022029-A1 Formulation and Process for Modulating Wound Healing SQSTM1, ATG7, TFEB LCK 4119/4885NQO2 3151/4885POLB 3227/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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