SCHEMBL18130123

SCHEMBL18130123

[N-]=[N+]=Nc1ccc(C=Cc2ccc(O)cc2)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NQO2 P16083 2/20 0.48
▸ LCK P06239 1/20 0.48
▸ APP P05067 6/20 0.47
▸ ALDH1A1 P00352 4/20 0.47
▸ MAPT P10636 4/20 0.47
▸ TP53 P04637 4/20 0.47
▸ KDM4E B2RXH2 3/20 0.47
▸ MEN1 O00255 3/20 0.47
▸ LMNA P02545 3/20 0.47
▸ HPGD P15428 3/20 0.47
▸ KMT2A Q03164 3/20 0.47
▸ SMN1; SMN2 Q16637 3/20 0.47
▸ HSD17B10 Q99714 3/20 0.47
▸ CA12 O43570 2/20 0.47
▸ CA1 P00915 2/20 0.47
▸ CA2 P00918 2/20 0.47
▸ CA3 P07451 2/20 0.47
▸ CA4 P22748 2/20 0.47
▸ CA6 P23280 2/20 0.47
▸ CA5A P35218 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18130122 1.00 NQO2 (0.48) NQO2LCKAPPALDH1A1MAPT
SCHEMBL23854165 0.89 CA1 (0.47) TP53CA12CA1CA2CA4
SCHEMBL13882617 0.89 CA1 (0.47) TP53CA12CA1CA2CA4
SCHEMBL13627732 0.87 TP53 (0.54) ALDH1A1MAPTTP53KDM4EMEN1
SCHEMBL17826850 0.87 PTGS1 (0.57) NQO2LCKAPPALDH1A1MAPT
SCHEMBL18130124 0.87 PTGS1 (0.57) NQO2LCKAPPALDH1A1MAPT
SCHEMBL18130069 0.83 PTGS2 (0.47) NQO2LCKALDH1A1MAPTTP53
SCHEMBL18130068 0.83 PTGS2 (0.47) NQO2LCKALDH1A1MAPTTP53
SCHEMBL18130091 0.83 LCK (0.61) NQO2LCKAPPALDH1A1MAPT
SCHEMBL18130090 0.83 LCK (0.61) NQO2LCKAPPALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3280402-B1 TOLAN COMPOUNDS FOR PROMOTING WOUND HEALING BIOMENDICS LLC (US) 2024-06-05 — — EP disclosed
US-11786481-B2 Formulation and process for modulating wound healing BioMendics, LLC (US) 2023-10-17 — — US disclosed
US-20210228501-A1 Formulation and Process for Modulating Wound Healing BioMendics, LLC (US) 2021-07-29 — — US disclosed
US-10426742-B2 Formulation and process for modulating wound healing BioMendics, LLC (US) 2019-10-01 — — US disclosed
US-20190022029-A1 Formulation and Process for Modulating Wound Healing BioMendics, LLC (US) 2019-01-24 — — US disclosed
US-20160296477-A1 Formulation and Process for Modulating Wound Healing BioMendics, LLC (US) 2016-10-13 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11786481-B2 Formulation and process for modulating wound healing SQSTM1, ATG7, TFEB NQO2 3151/4885LCK 4119/4885APP 4010/4885
US-20160296477-A1 Formulation and Process for Modulating Wound Healing SQSTM1, ATG7, TFEB NQO2 3288/4885LCK 4216/4885APP 4260/4885
US-20210228501-A1 Formulation and Process for Modulating Wound Healing ATG7, SQSTM1, ATF4 NQO2 3338/4885LCK 4007/4885APP 3850/4885
US-10426742-B2 Formulation and process for modulating wound healing SQSTM1, ATG7, TFEB NQO2 3151/4885LCK 4119/4885APP 4010/4885
US-20190022029-A1 Formulation and Process for Modulating Wound Healing SQSTM1, ATG7, TFEB NQO2 3151/4885LCK 4119/4885APP 4010/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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