Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.35 |
| ▸ | MLYCD | O95822 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.34 |
| ▸ | RORA | P35398 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | RORB | Q92753 | 1/20 | 0.34 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.34 |
| ▸ | LDLR | P01130 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18151606 | 0.98 | NFE2L2 (0.41) | NFE2L2NR1H2NR1H3HDAC6MLYCD | |
| SCHEMBL16799506 | 0.71 | AR (0.47) | NR1H2NR1H3MLYCDRORCKIF11 | |
| SCHEMBL16799948 | 0.70 | AR (0.51) | NFE2L2NR1H2NR1H3RORCKIF11 | |
| SCHEMBL9837839 | 0.70 | NFE2L2 (0.47) | NFE2L2NR1H2NR1H3HDAC6MLYCD | |
| SCHEMBL20423878 | 0.70 | NFE2L2 (0.55) | NFE2L2RORCKIF11LDLR | |
| SCHEMBL9837560 | 0.69 | NFE2L2 (0.40) | NFE2L2HDAC6MLYCDHSD11B1LDLR | |
| SCHEMBL18151473 | 0.68 | AR (0.43) | NR1H2NR1H3MLYCDHSD11B1KIF11 | |
| SCHEMBL16799610 | 0.68 | NR1H2 (0.46) | NR1H2NR1H3MLYCDKIF11RAB9A | |
| SCHEMBL9838902 | 0.68 | NFE2L2 (0.45) | NFE2L2HSD11B1KIF11LDLRCYP19A1 | |
| SCHEMBL16799842 | 0.67 | AR (0.43) | NR1H2NR1H3MLYCDHSD11B1KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107922337-B | ROR gamma modulators | 领先制药控股公司 | 2021-07-02 | — | — | CN | disclosed |
| EP-3319942-B1 | ROR-GAMMA MODULATORS | LEAD PHARMA B V (NL) | 2020-03-11 | — | — | EP | disclosed |
| CN-105980353-B | ROR gamma modulators | 领先制药控股公司 | 2019-06-14 | — | — | CN | disclosed |
| US-20190040012-A1 | ROR GAMMA (RORY) MODULATORS | LEAD PHARMA HOLDING B.V. (NL) | 2019-02-07 | — | — | US | disclosed |
| EP-3077372-B1 | ROR GAMMA (RORY) MODULATORS | LEAD PHARMA HOLDING BV (NL) | 2019-02-06 | — | — | EP | disclosed |
| US-20180141909-A1 | ROR GAMMA (RORY) MODULATORS | LEAD PHARMA HOLDING B.V. (NL) | 2018-05-24 | — | — | US | disclosed |
| US-20180141909-A1 | ROR GAMMA (RORY) MODULATORS | LEAD PHARMA HOLDING B.V. (NL) | 2018-05-24 | — | — | US | disclosed |
| EP-3319942-A1 | ROR GAMMA (RORY) MODULATORS | Lead Pharma Holding B.V. (NL) | 2018-05-16 | — | — | EP | disclosed |
| US-9738600-B2 | ROR gamma (RORγ) modulators | LEAD PHARMA CEL MODELS IP B.V. (NL) | 2017-08-22 | — | — | US | disclosed |
| US-9738600-B2 | ROR gamma (RORγ) modulators | LEAD PHARMA CEL MODELS IP B.V. (NL) | 2017-08-22 | — | — | US | disclosed |
| US-9738600-B2 | ROR gamma (RORγ) modulators | LEAD PHARMA CEL MODELS IP B.V. (NL) | 2017-08-22 | — | — | US | disclosed |
| WO-2016193468-A1 | ROR GAMMA (RORY) MODULATORS | LEAD PHARMA CEL MODELS IP B.V. (NL) | 2016-12-08 | — | — | WO | disclosed |
| WO-2016193468-A1 | ROR GAMMA (RORY) MODULATORS | LEAD PHARMA CEL MODELS IP B.V. (NL) | 2016-12-08 | — | — | WO | disclosed |
| EP-3101005-A1 | ROR GAMMA (RORY) MODULATORS | Lead Pharma Cel Models IP B.V. (NL) | 2016-12-07 | — | — | EP | disclosed |
| EP-3101005-A1 | ROR GAMMA (RORY) MODULATORS | Lead Pharma Cel Models IP B.V. (NL) | 2016-12-07 | — | — | EP | disclosed |
| US-20160304448-A1 | ROR GAMMA (RORy) MODULATORS | LEAD PHARMA CEL MODELS IP B.V. (NL) | 2016-10-20 | — | — | US | disclosed |
| US-20160304448-A1 | ROR GAMMA (RORy) MODULATORS | LEAD PHARMA CEL MODELS IP B.V. (NL) | 2016-10-20 | — | — | US | disclosed |
| US-20160304448-A1 | ROR GAMMA (RORy) MODULATORS | LEAD PHARMA CEL MODELS IP B.V. (NL) | 2016-10-20 | — | — | US | disclosed |
| CN-105980353-A | ROR gamma modulators | 领先制药CEL模型知识产权公司 | 2016-09-28 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190040012-A1 | ROR GAMMA (RORY) MODULATORS | RORC, RORA, RORB | NFE2L2 3042/4885NR1H2 24/4885NR1H3 22/4885 |
| US-20160304448-A1 | ROR GAMMA (RORy) MODULATORS | RORC, RORA, RORB | NFE2L2 2560/4885NR1H2 18/4885NR1H3 14/4885 |
| US-20180141909-A1 | ROR GAMMA (RORY) MODULATORS | RORC, RORA, RORB | NFE2L2 3242/4885NR1H2 28/4885NR1H3 27/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.