SCHEMBL1815536

SCHEMBL1815536

COc1ccc(C2(c3ccc(OCCO)cc3)C=Cc3c4c(c5cc(OC)c(OC)cc5c3O2)-c2ccc(C(F)(F)F)cc2C4(C)C)cc1

nearest known ligand 0.34

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PTGDR2 Q9Y5Y4 1/20 0.34
ALK Q9UM73 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30750473 1.00 PTGDR2 (0.34) PTGDR2ALK
SCHEMBL3953598 0.93 ALK (0.34) ALK
SCHEMBL1815096 0.92 ALK (0.33) PTGDR2ALK
SCHEMBL29664172 0.92 RAB9A (0.32)
SCHEMBL3959108 0.92 RAB9A (0.32)
SCHEMBL3955033 0.92 ALK (0.33) ALK
SCHEMBL3958868 0.92 LMNA (0.36) PTGDR2ALK
SCHEMBL3956773 0.90 TNIK (0.35)
SCHEMBL4188623 0.89 PAX8 (0.31)
SCHEMBL25605282 0.89 TP53 (0.33)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2078006-B1 PHOTOCHROMIC MATERIALS DEMONSTRATING IMPROVED FADE RATES TRANSITIONS OPTICAL INC (US) 2018-11-07 EP claimed
US-8748634-B2 Photochromic materials demonstrating improved fade rates TRANSITIONS OPTICAL, INC. (US) 2014-06-10 US claimed
EP-2078006-A2 PHOTOCHROMIC MATERIALS DEMONSTRATING IMPROVED FADE RATES TRANSITIONS OPTICAL, INC. (US) 2009-07-15 EP claimed
WO-2008054942-A2 PHOTOCHROMIC MATERIALS DEMONSTRATING IMPROVED FADE RATES TRANSITIONS OPTICAL, INC. (US) 2008-05-08 WO claimed
US-20080103301-A1 PHOTOCHROMIC MATERIALS DEMONSTRATING IMPROVED FADE RATES TRANSITIONS OPTICAL, INC. (US) 2008-05-01 US claimed
EP-2545095-B1 METHODS FOR PRODUCING PHOTOSENSITIVE MICROPARTICLES, NON-AQUEOUS DISPERSIONS THEREOF AND ARTICLES PREPARED THEREWITH TRANSITIONS OPTICAL INC (US) 2024-01-24 EP disclosed
EP-2078006-B1 PHOTOCHROMIC MATERIALS DEMONSTRATING IMPROVED FADE RATES TRANSITIONS OPTICAL INC (US) 2018-11-07 EP disclosed
EP-2545140-B1 METHODS FOR PRODUCING PHOTOSENSITIVE MICROPARTICLES TRANSITIONS OPTICAL INC (US) 2017-06-21 EP disclosed
EP-2494408-B9 PHOTOCHROMIC MATERIALS TRANSITIONS OPTICAL INC (US) 2015-09-02 EP disclosed
EP-2494408-B1 PHOTOCHROMIC MATERIALS TRANSITIONS OPTICAL INC (US) 2015-04-15 EP disclosed
US-9006427-B2 Photochromic materials demonstrating improved fade rates TRANSITIONS OPTICAL, INC. (US) 2015-04-14 US disclosed
US-8748634-B2 Photochromic materials demonstrating improved fade rates TRANSITIONS OPTICAL, INC. (US) 2014-06-10 US disclosed
US-20120136148-A1 Photochromic Compounds Having At Least Two Photochromic Moieties TRANSITIONS OPTICAL, INC. (US) 2012-05-31 US disclosed
WO-2011112327-A1 METHODS FOR PRODUCING PHOTOSENSITIVE MICROPARTICLES TRANSITIONS OPTICAL, INC. (US) 2011-09-15 WO disclosed
US-20110108781-A1 PHOTOCHROMIC MATERIALS TRANSITIONS OPTICAL, INC. (US) 2011-05-12 US disclosed
US-20100221661-A1 METHODS FOR PRODUCING PHOTOSENSITIVE MICROPARTICLES TRANSITIONS OPTICAL, INC. (US) 2010-09-02 US disclosed
US-20100209697-A1 METHODS FOR PRODUCING PHOTOSENSITIVE MICROPARTICLES, NON-AQUEOUS DISPERSIONS THEREOF AND ARTICLES PREPARED THEREWITH TRANSITIONS OPTICAL, INC. (US) 2010-08-19 US disclosed
EP-2078006-A2 PHOTOCHROMIC MATERIALS DEMONSTRATING IMPROVED FADE RATES TRANSITIONS OPTICAL, INC. (US) 2009-07-15 EP disclosed
WO-2008054942-A2 PHOTOCHROMIC MATERIALS DEMONSTRATING IMPROVED FADE RATES TRANSITIONS OPTICAL, INC. (US) 2008-05-08 WO disclosed
US-20080103301-A1 PHOTOCHROMIC MATERIALS DEMONSTRATING IMPROVED FADE RATES TRANSITIONS OPTICAL, INC. (US) 2008-05-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080103301-A1 PHOTOCHROMIC MATERIALS DEMONSTRATING IMPROVED FADE RATES PNPO, FLAD1, CRY2 PTGDR2 407/4885ALK 2815/4885
US-20110108781-A1 PHOTOCHROMIC MATERIALS INCENP, SMCHD1, NEDD8 PTGDR2 974/4885ALK 1877/4885
US-20120136148-A1 Photochromic Compounds Having At Least Two Photochromic Moieties CRY2, PCNA, MTCL3 PTGDR2 4035/4885ALK 3290/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.