Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.35 |
| ▸ | PLK4 | O00444 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL789190 | 0.88 | MAOA (0.46) | MAOAPOLBHTR2BALDH1A1MAPK1 | |
| SCHEMBL30430068 | 0.88 | MAOA (0.46) | MAOAPOLBHTR2BALDH1A1MAPK1 | |
| SCHEMBL19494737 | 0.86 | MAOA (0.45) | MAOAPOLBHTR2BALDH1A1MAPK1 | |
| SCHEMBL21703801 | 0.78 | PNMT (0.41) | MAOAPOLBHTR2BALDH1A1MAPK1 | |
| SCHEMBL18156787 | 0.78 | PNMT (0.52) | MAOAHTR2BALDH1A1MAPK1MAPT | |
| SCHEMBL20222295 | 0.77 | LMNA (0.38) | MAOAPOLBHTR2BALDH1A1MAPK1 | |
| SCHEMBL18156788 | 0.77 | PDK2 (0.38) | MAOAPOLBHTR2BALDH1A1MAPT | |
| SCHEMBL18156792 | 0.77 | PDK2 (0.48) | MAOAPOLBHTR2BALDH1A1MAPT | |
| SCHEMBL29359219 | 0.76 | ALDH1A1 (0.52) | MAOAPOLBHTR2BALDH1A1MAPK1 | |
| SCHEMBL30681697 | 0.76 | ALDH1A1 (0.52) | MAOAPOLBHTR2BALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230126850-A1 | HETEROCYCLIC SPIRO COMPOUNDS | MERCK PATENT GMBH (DE) | 2023-04-27 | — | — | US | disclosed |
| US-20180159044-A1 | COMPOUND AND ORGANIC ELECTRONIC DEVICE USING THE SAME | NICHEM FINE TECHNOLOGY CO., LTD. (TW) | 2018-06-07 | — | — | US | disclosed |
| US-20180047918-A1 | COMPOUND AND ORGANIC ELECTRONIC DEVICE USING THE SAME | NICHEM FINE TECHNOLOGY CO., LTD. (TW) | 2018-02-15 | — | — | US | disclosed |
| US-20160308147-A1 | HETEROCYCLIC SPIRO COMPOUNDS | MERCK PATENT GMBH (DE) | 2016-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160308147-A1 | HETEROCYCLIC SPIRO COMPOUNDS | NES, KCNC1, HCN4 | MAOA 3085/4885POLB 3232/4885HTR2B 2447/4885 |
| US-20180047918-A1 | COMPOUND AND ORGANIC ELECTRONIC DEVICE USING THE SAME | ORC3, AOX1, RCOR3 | MAOA 1867/4885POLB 1982/4885HTR2B 3046/4885 |
| US-20230126850-A1 | HETEROCYCLIC SPIRO COMPOUNDS | NES, KCNC1, HCN4 | MAOA 3085/4885POLB 3232/4885HTR2B 2447/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.