Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | CDK1 | P06493 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | RORC | P51449 | 1/20 | 0.46 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.45 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.44 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1817861 | 0.88 | ALDH1A1 (0.48) | ALDH1A1CDK1HPGDRORCATAD2 | |
| SCHEMBL539699 | 0.81 | ALDH1A1 (0.73) | ALDH1A1CDK1ATAD2CECR2RAB9A | |
| SCHEMBL686781 | 0.79 | ALDH1A1 (0.54) | ALDH1A1CDK1ATAD2CECR2RAB9A | |
| SCHEMBL6770516 | 0.79 | ALDH1A1 (0.54) | ALDH1A1CDK1ATAD2CECR2RAB9A | |
| SCHEMBL3026745 | 0.78 | HSD17B10 (0.53) | ALDH1A1HPGDRORCPOLBRAB9A | |
| SCHEMBL6771522 | 0.78 | ALDH1A1 (0.59) | ALDH1A1CDK1ATAD2CECR2POLB | |
| SCHEMBL10719928 | 0.78 | ATAD2 (0.65) | ALDH1A1CDK1RORCATAD2CECR2 | |
| SCHEMBL14368008 | 0.77 | RORC (0.58) | RORCATAD2CECR2POLBRAB9A | |
| SCHEMBL2436014 | 0.77 | RORC (0.66) | ALDH1A1CDK1RORCPOLBMAPT | |
| SCHEMBL16371264 | 0.76 | ALDH1A1 (0.40) | ALDH1A1HPGDPOLBMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8461134-B2 | Boron-containing small molecules | ANACOR PHARMACEUTICALS, INC. (US) | 2013-06-11 | — | — | US | disclosed |
| US-20110172187-A1 | BORON-CONTAINING SMALL MOLECULES | ANACOR PHARMACEUTICALS, INC. (US) | 2011-07-14 | — | — | US | disclosed |
| WO-2011060196-A1 | BORON-CONTAINING SMALL MOLECULES | ANACOR PHARMACEUTICALS, INC. (US) | 2011-05-19 | — | — | WO | disclosed |
| US-7579378-B2 | Sulfonamido compounds that antagonize the vanilloid TRPV1 receptor | PHARMESTE S.R.L. (IT) | 2009-08-25 | — | — | US | disclosed |
| US-20090118374-A1 | SULFONAMIDO COMPOUNDS THAT ANTAGONISE THE VANILLOID TRPV1 RECEPTOR | PHARMESTE S.R.L. (IT) | 2009-05-07 | — | — | US | disclosed |
| EP-1805138-B1 | SULFONAMIDO COMPOUNDS THAT ANTAGONISE THE VANILLOID TRPV1 RECEPTOR | PHARMESTE SRL (IT) | 2008-03-19 | — | — | EP | disclosed |
| US-5516906-A | Process for the preparation of N-[2-[4-(aminosulfonyl) phenyl]ethyl]5-methylpyrazinecarboxamide | USV LIMITED (IN) | 1996-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110172187-A1 | BORON-CONTAINING SMALL MOLECULES | BCL6B, BCL6, BTD | ALDH1A1 4190/4885CDK1 2617/4885HPGD 4100/4885 |
| US-20090118374-A1 | SULFONAMIDO COMPOUNDS THAT ANTAGONISE THE VANILLOID TRPV1 RECEPTOR | TRPV1, TRPA1, TRPV4 | ALDH1A1 1697/4885CDK1 1827/4885HPGD 2000/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.