SCHEMBL182030

SCHEMBL182030

CC(C)(C)OC(=O)N1CCCC(C(=O)N[C@@H](CCc2ccccc2)C(=O)N2CCC(N3C(=O)C(C)(C)c4ccccc43)CC2)C1

nearest known ligand 0.47

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 1/20 0.45
KMT2A Q03164 6/20 0.44
MEN1 O00255 3/20 0.44
ALDH1A1 P00352 1/20 0.44
ITGB3 P05106 3/20 0.42
ITGA2B P08514 3/20 0.42
L3MBTL1 Q9Y468 1/20 0.40
STS P08842 1/20 0.39
CCKBR P32239 1/20 0.38
USP30 Q70CQ3 1/20 0.37
HSD11B1 P28845 1/20 0.37
JAK2 O60674 1/20 0.37
JAK1 P23458 1/20 0.37
GPR119 Q8TDV5 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31163618 1.00 MAPK1 (0.45) MAPK1KMT2AMEN1ALDH1A1ITGB3
SCHEMBL182031 1.00 MAPK1 (0.45) MAPK1KMT2AMEN1ALDH1A1ITGB3
SCHEMBL15640769 0.91 ALDH1A1 (0.43) MAPK1KMT2AMEN1ALDH1A1L3MBTL1
SCHEMBL181801 0.88 CCKBR (0.41) MAPK1KMT2AMEN1ALDH1A1L3MBTL1
SCHEMBL181802 0.88 CCKBR (0.41) MAPK1KMT2AMEN1ALDH1A1L3MBTL1
SCHEMBL180948 0.87 KMT2A (0.47) MAPK1KMT2AMEN1ALDH1A1ITGB3
SCHEMBL180947 0.87 KMT2A (0.47) MAPK1KMT2AMEN1ALDH1A1ITGB3
SCHEMBL181676 0.84 CCKBR (0.44) MAPK1KMT2AMEN1ALDH1A1CCKBR
SCHEMBL181677 0.84 CCKBR (0.44) MAPK1KMT2AMEN1ALDH1A1CCKBR
SCHEMBL181545 0.84 CCKBR (0.43) MAPK1KMT2AMEN1ALDH1A1CCKBR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260146036-A1 CRYSTALLINE FORMS RAQUALIA PHARMA INC. (JP) 2026-05-28 US disclosed
EP-4377309-A1 CRYSTALLINE FORMS RaQualia Pharma Inc. (JP) 2024-06-05 EP disclosed
CN-117616022-A Crystalline forms 拉夸里亚创药株式会社 2024-02-27 CN disclosed
WO-2023008585-A1 CRYSTALLINE FORMS RAQUALIA PHARMA INC. (JP) 2023-02-02 WO disclosed
EP-2401268-B1 OXYINDOLE DERIVATIVES WITH MOTILIN RECEPTOR AGONISTIC ACTIVITY RAQUALIA PHARMA INC (JP) 2015-07-29 EP disclosed
US-8697877-B2 Oxyindole derivatives with motilin receptor agonistic activity RAQUALIA PHARMA INC. (JP) 2014-04-15 US disclosed
EP-2401268-A1 OXYINDOLE DERIVATIVES WITH MOTILIN RECEPTOR AGONISTIC ACTIVITY RaQualia Pharma Inc (JP) 2012-01-04 EP disclosed
US-20110312933-A1 OXYINDOLE DERIVATIVES WITH MOTILIN RECEPTOR AGONISTIC ACTIVITY RAQUALIA PHARMA INC. (JP) 2011-12-22 US disclosed
WO-2010098145-A1 OXYINDOLE DERIVATIVES WITH MOTILIN RECEPTOR AGONISTIC ACTIVITY RAQUALIA PHARMA INC. (JP) 2010-09-02 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110312933-A1 OXYINDOLE DERIVATIVES WITH MOTILIN RECEPTOR AGONISTIC ACTIVITY GPR68, GPR88, GPR52 MAPK1 337/4885KMT2A 3436/4885MEN1 1651/4885
US-20260146036-A1 CRYSTALLINE FORMS PRKCD, CCT8, CRYZ MAPK1 735/4885KMT2A 342/4885MEN1 1387/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.