Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 10/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | STAT3 | P40763 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | BTK | Q06187 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.44 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18230428 | 0.87 | MAPT (0.46) | LRRK2MAPTSTAT3SMN1; SMN2ALDH1A1 | |
| SCHEMBL18230368 | 0.86 | TRPV4 (0.46) | LRRK2MAPTSTAT3SMN1; SMN2 | |
| SCHEMBL18094547 | 0.84 | LRRK2 (0.57) | LRRK2MAPTSTAT3SMN1; SMN2BTK | |
| SCHEMBL18230481 | 0.79 | STAT3 (0.47) | MAPTSTAT3SMN1; SMN2LMNA | |
| SCHEMBL18230400 | 0.78 | TRPV4 (0.56) | LRRK2MAPTSTAT3SMN1; SMN2LMNA | |
| SCHEMBL18230378 | 0.77 | MPL (0.49) | STAT3 | |
| SCHEMBL21753690 | 0.76 | LRRK2 (1.00) | LRRK2 | |
| SCHEMBL18230422 | 0.76 | LRRK2 (0.56) | LRRK2MAPTSTAT3SMN1; SMN2BTK | |
| SCHEMBL18094571 | 0.75 | LRRK2 (0.46) | LRRK2MAPTSTAT3SMN1; SMN2LMNA | |
| SCHEMBL18230521 | 0.75 | TRPV1 (0.59) | MAPTSTAT3SMN1; SMN2LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016183173-A1 | ANTIPARASITIC COMPOUNDS | Avista Pharma Solutions (US) | 2016-11-17 | — | — | WO | disclosed |
| WO-2016183173-A1 | ANTIPARASITIC COMPOUNDS | Avista Pharma Solutions (US) | 2016-11-17 | — | — | WO | disclosed |