Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | USP2 | O75604 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.46 |
| ▸ | ITK | Q08881 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CCND1 | P24385 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | CCND3 | P30281 | 1/20 | 0.42 |
| ▸ | CDK7 | P50613 | 1/20 | 0.42 |
| ▸ | CCNH | P51946 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18230368 | 0.89 | TRPV4 (0.46) | MAPTLRRK2SMN1; SMN2LCKHCK | |
| SCHEMBL18230388 | 0.87 | LRRK2 (0.61) | MAPTLRRK2ALDH1A1SMN1; SMN2HIF1A | |
| SCHEMBL18230451 | 0.79 | TRPV4 (0.59) | MAPTMAPK1ITKALDH1A1SMN1; SMN2 | |
| SCHEMBL18230481 | 0.78 | STAT3 (0.47) | MAPTMAPK1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL18094555 | 0.75 | SMN1; SMN2 (0.52) | MAPTLRRK2CCND3CDK6SMN1; SMN2 | |
| SCHEMBL18230378 | 0.75 | MPL (0.49) | TRPV1STAT3 | |
| SCHEMBL18094509 | 0.74 | GPR119 (0.47) | MAPTLRRK2CYP2C19SMN1; SMN2WNT3A | |
| SCHEMBL18094571 | 0.74 | LRRK2 (0.46) | MAPTTP53MAPK1LRRK2SMN1; SMN2 | |
| SCHEMBL18230521 | 0.73 | TRPV1 (0.59) | MAPTMAPK1ALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL18094563 | 0.73 | LRRK2 (0.45) | MAPTTP53MAPK1LRRK2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016183173-A1 | ANTIPARASITIC COMPOUNDS | Avista Pharma Solutions (US) | 2016-11-17 | — | — | WO | disclosed |