SCHEMBL1827367

SCHEMBL1827367

CC(=O)C(O)[C@H]1O[C@@H](n2cc(C)c(=O)[nH]c2=O)C[C@@]1(O)C(C)=O

nearest known ligand 0.45

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
TK1 P04183 4/20 0.44
DHFR P00374 1/20 0.42
TK2 O00142 1/20 0.40
ALDH1A1 P00352 1/20 0.40
LMNA P02545 1/20 0.40
ALB P02768 1/20 0.40
POLB P06746 1/20 0.40
ADRA1A P35348 1/20 0.40
BLM P54132 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4364016 0.88 ALDH1A1 (0.43) TK1ALDH1A1POLB
SCHEMBL9744721 0.88 LMNA (0.43) TK1LMNA
SCHEMBL6258952 0.88 TK1 (0.43) TK1BLM
SCHEMBL8176114 0.87 TK1 (0.33) TK1DHFR
SCHEMBL8167928 0.85 TK2 (0.37) TK1TK2
SCHEMBL9803727 0.84 TK1 (0.36) TK1TK2
SCHEMBL4366634 0.81 SLC28A1 (0.36)
SCHEMBL4064057 0.81 TK1 (0.38) TK1ALDH1A1LMNAALBPOLB
SCHEMBL551408 0.80 TK1 (0.49) TK1ALDH1A1LMNAALBPOLB
SCHEMBL10385764 0.80 TK1 (0.41) TK1DHFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4707286-A1 HIGHLY LIPID-SOLUBLE NUCLEOTIDE BUILDING BLOCK FOR OLIGONUCLEOTIDE SYNTHESIS, AND SYNTHESIS OF OLIGONUCLEOTIDES USING SAME Natias Inc. (JP) 2026-03-11 EP disclosed
US-20250171482-A1 DEACYLATION OF CARBOHYDRATE COMPOUNDS UNIVERSITY OF SOUTH ALABAMA 2025-05-29 US disclosed
WO-2024228396-A1 HIGHLY LIPID-SOLUBLE NUCLEOTIDE BUILDING BLOCK FOR OLIGONUCLEOTIDE SYNTHESIS, AND SYNTHESIS OF OLIGONUCLEOTIDES USING SAME 株式会社ナティアス 2024-11-07 WO disclosed
CN-118632856-A By bringing the carbohydrate deacylation of the substance 益力舒健康公司 2024-09-10 CN disclosed
EP-2356246-B1 Biocatalytic preparation of 5-methyluridine CSIR (ZA) 2012-08-22 EP disclosed
EP-2356246-A1 BIOCATALYTIC PREPARATION OF NUCLEOSIDES CSIR (ZA) 2011-08-17 EP disclosed
EP-1348712-B1 Processes and intermediates in the synthesis of L-thymidine MITSUI CHEMICALS INC (JP) 2011-05-04 EP disclosed
WO-2010055369-A1 BIOCATALYTIC PREPARATION OF NUCLEOSIDES CSIR (ZA) 2010-05-20 WO disclosed
US-7125983-B2 L-nucleic acid derivatives and process for the synthesis thereof MITSUI CHEMICALS, INC. (JP) 2006-10-24 US disclosed
US-20040063926-A1 L-nucleic acid derivative and processes for the synthesis thereof MITSUI CHEMICALS, INC. (JP) 2004-04-01 US disclosed
EP-1348712-A1 L-NUCLEIC ACID DERIVATIVES AND PROCESSES FOR THE SYNTHESIS THEREOF Mitsui Chemicals, Inc. (JP) 2003-10-01 EP disclosed
EP-1041159-A2 Method, oligonucleotides suitable for the degradation of in vitro synthesized nucleic acid molecules MIRA Diagnostika GmbH (DE) 2000-10-04 EP disclosed
US-5175273-A Pyridinone or pyrimidinone nucleoside bases containing fused aromatic polycyclic rings GENENTECH, INC. (US) 1992-12-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250171482-A1 DEACYLATION OF CARBOHYDRATE COMPOUNDS FUT5, DDOST, TREH TK1 3510/4885DHFR 1893/4885TK2 3434/4885
US-20040063926-A1 L-nucleic acid derivative and processes for the synthesis thereof TYMS, RNGTT, DTYMK TK1 23/4885DHFR 26/4885TK2 44/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.