Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | KIF11 | P52732 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PTGIR | P43119 | 4/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18286173 | 0.84 | LMNA (0.39) | KIF11LMNAMEN1HPGDKMT2A | |
| SCHEMBL3887176 | 0.83 | CYP2C19 (0.50) | CYP2C19HIF1ASMN1; SMN2CYP3A4KMT2A | |
| SCHEMBL15678398 | 0.80 | CYP2C19 (0.52) | KIF11LMNACYP2C19HIF1ASMN1; SMN2 | |
| SCHEMBL25758756 | 0.73 | CTSL (0.43) | KIF11LMNATSHRCYP2C19SMN1; SMN2 | |
| SCHEMBL9911069 | 0.72 | IDO1 (0.53) | FFAR1CYP3A4MEN1KMT2A | |
| SCHEMBL1698139 | 0.72 | CNR1 (0.50) | KIF11LMNACYP2C19CYP3A4CYP2D6 | |
| SCHEMBL7039820 | 0.72 | ACHE (0.44) | KIF11LMNACYP2C19CYP3A4CYP2D6 | |
| Toluene SCHEMBL29913501 | 0.72 | TSHR (0.50) | FFAR1LMNAPTGIRPTGDR2TSHR | |
| SCHEMBL7908308 | 0.71 | LMNA (0.43) | KIF11LMNACYP2C19CYP3A4CYP2D6 | |
| SCHEMBL1653535 | 0.71 | KIF11 (0.45) | KIF11LMNACYP2C19SMN1; SMN2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10758522-B2 | Small molecule analogs of the nemo binding peptide | THE SCRIPPS RESEARCH INSTITUTE (US) | 2020-09-01 | — | — | US | disclosed |
| US-20180169078-A1 | Small Molecule Analogs of the Nemo Binding Peptide | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED | 2018-06-21 | — | — | US | disclosed |
| EP-3302468-A1 | SMALL MOLECULE ANALOGS OF THE NEMO BINDING PEPTIDE | The Scripps Research Institute (US) | 2018-04-11 | — | — | EP | disclosed |
| WO-2016196117-A1 | SMALL MOLECULE ANALOGS OF THE NEMO BINDING PEPTIDE | THE SCRIPPS RESEARCH INSTITUTE (US) | 2016-12-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10758522-B2 | Small molecule analogs of the nemo binding peptide | IKBKG, NFKBIA, NFKB1 | FFAR1 2508/4885KIF11 3603/4885LMNA 1366/4885 |
| US-20180169078-A1 | Small Molecule Analogs of the Nemo Binding Peptide | IKBKG, NFKBIA, NFKB1 | FFAR1 2508/4885KIF11 3603/4885LMNA 1366/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.