SCHEMBL1829458

SCHEMBL1829458

CNC(=O)OC(c1cn(S(=O)(=O)c2cncc(C)c2)c(-c2cccnc2F)c1F)C(C)(C)C

nearest known ligand 0.32

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
RORC P51449 2/20 0.32
NAMPT P43490 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1832698 0.93 RORC (0.32) RORCNAMPT
SCHEMBL1837632 0.88 PTGS2 (0.30)
SCHEMBL2408490 0.86 HTR6 (0.35)
SCHEMBL4425554 0.86 RORC (0.33) RORCNAMPT
SCHEMBL4425656 0.86 MET (0.39)
SCHEMBL1831693 0.85
SCHEMBL2412509 0.84
SCHEMBL2410027 0.84 NTRK1 (0.31)
SCHEMBL2411543 0.83 ALDH1A1 (0.30)
SCHEMBL1835872 0.83 GRM4 (0.31)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2318390-A1 PYRROLE COMPOUNDS Takeda Pharmaceutical Company Limited (JP) 2011-05-11 EP disclosed
WO-2010024451-A1 PYRROLE COMPOUNDS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2010-03-04 WO disclosed