Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 4/20 | 0.36 |
| ▸ | NMT1 | P30419 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.31 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.31 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.31 |
| ▸ | FEN1 | P39748 | 2/20 | 0.31 |
| ▸ | FYN | P06241 | 1/20 | 0.31 |
| ▸ | TDO2 | P48775 | 1/20 | 0.30 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.30 |
| ▸ | INSR | P06213 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18306366 | 0.84 | FYN (0.36) | GRM5FYN | |
| SCHEMBL18306342 | 0.83 | KMT2A (0.40) | KMT2AGABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL18306348 | 0.83 | RPS6KA3 (0.37) | CYP2A6GRIN1GRIN2BALOX5APFEN1 | |
| SCHEMBL18306300 | 0.81 | USP7 (0.34) | CYP2A6KMT2AALOX5APFEN1SRC | |
| SCHEMBL18306341 | 0.78 | ADORA1 (0.42) | ABL1CYP2A6KMT2AFYNPDGFRB | |
| SCHEMBL18306367 | 0.76 | AURKA (0.37) | ABL1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL18306344 | 0.74 | MAP4K4 (0.37) | ABL1GRIN2BALOX5APFEN1RET | |
| SCHEMBL18306345 | 0.73 | PTGS2 (0.39) | ALOX5APFEN1RETFGFR1LTK | |
| SCHEMBL19661452 | 0.72 | KDM1A (0.35) | KMT2AALOX5APFEN1 | |
| SCHEMBL16473227 | 0.71 | TRPA1 (0.55) | EGFRFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170342048-A1 | GDF-8 Inhibitors | MIDCAP FINANCIAL TRUST | 2017-11-30 | — | — | US | disclosed |
| US-9518040-B2 | GDF-8 inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2016-12-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170342048-A1 | GDF-8 Inhibitors | MSTN, MYOF, CXCL8 | ABL1 2930/4885NMT1 1497/4885CYP2A6 4255/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.