Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 8/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 7/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 2/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.34 |
| ▸ | HTR5A | P47898 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18306300 | 0.85 | USP7 (0.34) | KMT2AFEN1ALOX5AP | |
| SCHEMBL18306348 | 0.84 | RPS6KA3 (0.37) | MAP4K4FEN1ALOX5APFGFR1MAPK14 | |
| SCHEMBL18306447 | 0.84 | KDM4E (0.40) | MAP4K4FEN1ALOX5APBACE1FGFR1 | |
| SCHEMBL18306366 | 0.83 | FYN (0.36) | MAP4K4ADORA2AADORA1 | |
| SCHEMBL18306343 | 0.83 | ABL1 (0.36) | KMT2AFEN1ALOX5APBACE1FGFR1 | |
| SCHEMBL18306341 | 0.81 | ADORA1 (0.42) | KMT2AMAP4K4FGFR1ADORA2AADORA1 | |
| SCHEMBL18306344 | 0.74 | MAP4K4 (0.37) | MAP4K4FEN1ALOX5APFGFR1LCK | |
| SCHEMBL18306367 | 0.74 | AURKA (0.37) | MAP4K4FEN1ALOX5APFGFR1GABRG2 | |
| SCHEMBL18306345 | 0.74 | PTGS2 (0.39) | MAP4K4FEN1ALOX5APFGFR1MAPK14 | |
| SCHEMBL18306302 | 0.73 | MAP4K4 (0.44) | MAP4K4FEN1ALOX5APBACE1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170342048-A1 | GDF-8 Inhibitors | MIDCAP FINANCIAL TRUST | 2017-11-30 | — | — | US | disclosed |
| US-9518040-B2 | GDF-8 inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2016-12-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170342048-A1 | GDF-8 Inhibitors | MSTN, MYOF, CXCL8 | KMT2A 4190/4885MAP4K4 2844/4885FEN1 1544/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.