Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 4/20 | 0.36 |
| ▸ | IDH1 | O75874 | 6/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KDM5A | P29375 | 1/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | PLK1 | P53350 | 1/20 | 0.33 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.32 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ASPH | Q12797 | 1/20 | 0.32 |
| ▸ | RIOX2 | Q8IUF8 | 1/20 | 0.32 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18308541 | 0.94 | MET (0.35) | METIDH1PDGFRBPDGFRA | |
| SCHEMBL18308416 | 0.93 | GAA (0.33) | METIDH1KDM4E | |
| SCHEMBL18308537 | 0.93 | MAPT (0.36) | METIDH1PDGFRBPDGFRAPLK1 | |
| SCHEMBL18308323 | 0.92 | IDH1 (0.34) | METIDH1KITKDM4E | |
| SCHEMBL18308539 | 0.91 | MET (0.37) | METIDH1PDGFRBPDGFRAKDM4E | |
| SCHEMBL18308542 | 0.91 | PLK1 (0.32) | IDH1PLK1KDM4E | |
| SCHEMBL18308332 | 0.90 | KIT (0.35) | METIDH1PLK1KIT | |
| SCHEMBL18308344 | 0.87 | KIT (0.36) | METIDH1PDGFRBPDGFRAKIT | |
| SCHEMBL18308394 | 0.86 | APLNR (0.33) | METIDH1KDM5AKDM5B | |
| SCHEMBL18308334 | 0.86 | MAPT (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016199943-A1 | HETEROCYCLIC COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-12-15 | — | — | WO | disclosed |