SCHEMBL18394918

SCHEMBL18394918

CCOC(=O)c1cnn(-c2ccc(C(F)(F)F)nc2)c1N1CCOCC1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPK1 P28482 3/20 0.51
▸ TP53 P04637 2/20 0.51
▸ USP2 O75604 1/20 0.51
▸ RECQL P46063 1/20 0.51
▸ HSD17B10 Q99714 1/20 0.51
▸ LMNA P02545 3/20 0.46
▸ SMN1; SMN2 Q16637 5/20 0.45
▸ MAPT P10636 11/20 0.45
▸ GAA P10253 8/20 0.45
▸ RAB9A P51151 2/20 0.44
▸ NPC1 O15118 1/20 0.44
▸ TDP1 Q9NUW8 3/20 0.44
▸ L3MBTL1 Q9Y468 3/20 0.44
▸ MEN1 O00255 2/20 0.44
▸ KMT2A Q03164 2/20 0.44
▸ MC4R P32245 2/20 0.44
▸ HTT P42858 2/20 0.44
▸ PTK2B Q14289 1/20 0.44
▸ NPSR1 Q6W5P4 1/20 0.44
▸ CLK1 P49759 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18412907 0.86 PRKDC (0.43) MAPTALDH1A1
SCHEMBL18394819 0.81 TP53 (0.49) MAPK1TP53USP2RECQLHSD17B10
SCHEMBL20098725 0.80 RAB9A (0.67) TP53RECQLHSD17B10SMN1; SMN2MAPT
SCHEMBL14405717 0.75 POLB (0.47) MAPK1TP53USP2RECQLHSD17B10
SCHEMBL20495244 0.72 MAPK1 (0.48) MAPK1TP53USP2RECQLHSD17B10
SCHEMBL24075719 0.71 HSD17B10 (0.54) MAPK1TP53USP2RECQLHSD17B10
SCHEMBL18394475 0.70 USP2 (0.44) MAPK1TP53USP2RECQLHSD17B10
SCHEMBL30147877 0.70 TRPC1 (0.60) SMN1; SMN2MAPTGAARAB9ANPC1
SCHEMBL23510303 0.70 TRPC1 (0.60) SMN1; SMN2MAPTGAARAB9ANPC1
SCHEMBL19807687 0.70 DGAT1 (0.48) LMNARAB9ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12268694-B2 Combination pharmaceutical agents as RSV inhibitors ENANTA PHARMACEUTICALS, INC. (US) 2025-04-08 — — US disclosed
EP-3687543-B1 COMBINATIONS OF PHARMACEUTICAL AGENTS AS RSV INHIBITORS ENANTA PHARM INC (US) 2024-03-20 — — EP disclosed
CN-111386118-B Combination pharmaceutical agents as RSV inhibitors 英安塔制药有限公司 2023-05-09 — — CN disclosed
US-20220323460-A1 COMBINATION PHARMACEUTICAL AGENTS AS RSV INHIBITORS ENANTA PHARM INC (US) 2022-10-13 — — US disclosed
EP-3324977-B1 BENZODIAZEPINE DERIVATIVES AS RSV INHIBITORS ENANTA PHARM INC (US) 2022-07-13 — — EP disclosed
EP-3324977-B1 BENZODIAZEPINE DERIVATIVES AS RSV INHIBITORS ENANTA PHARM INC (US) 2022-07-13 — — EP disclosed
CN-108200760-B Benzodiazepine derivatives as RSV inhibitors 英安塔制药有限公司 2022-04-01 — — CN disclosed
US-10881666-B2 Combination pharmaceutical agents as RSV inhibitors ENANTA PHARMACEUTICALS, INC. (US) 2021-01-05 — — US disclosed
US-10881666-B2 Combination pharmaceutical agents as RSV inhibitors ENANTA PHARMACEUTICALS, INC. (US) 2021-01-05 — — US disclosed
US-10865215-B2 Benzodiazepine derivatives as RSV inhibitors ENANTA PHARMACEUTICALS, INC. (US) 2020-12-15 — — US disclosed
EP-3687543-A1 COMBINATION PHARMACEUTICAL AGENTS AS RSV INHIBITORS Enanta Pharmaceuticals, Inc. (US) 2020-08-05 — — EP disclosed
US-20200223867-A1 BENZODIAZEPINE DERIVATIVES AS RSV INHIBITORS ENANTA PHARM INC (US) 2020-07-16 — — US disclosed
CN-111386118-A Combination pharmaceutical agents as RSV inhibitors 英安塔制药有限公司 2020-07-07 — — CN disclosed
US-10570153-B2 Benzodiazepine derivatives as RSV inhibitors ENANTA PHARMACEUTICALS, INC. (US) 2020-02-25 — — US disclosed
US-20190192535-A1 COMBINATION PHARMACEUTICAL AGENTS AS RSV INHIBITORS ENANTA PHARMACEUTICALS, INC. 2019-06-27 — — US disclosed
US-20190192535-A1 COMBINATION PHARMACEUTICAL AGENTS AS RSV INHIBITORS ENANTA PHARMACEUTICALS, INC. 2019-06-27 — — US disclosed
WO-2019067864-A1 COMBINATION PHARMACEUTICAL AGENTS AS RSV INHIBITORS ENANTA PHARMACEUTICALS, INC. (US) 2019-04-04 — — WO disclosed
US-9957281-B2 Benzodiazepine derivatives as RSV inhibitors ENANTA PHARMACEUTICALS, INC. (US) 2018-05-01 — — US disclosed
US-9957281-B2 Benzodiazepine derivatives as RSV inhibitors ENANTA PHARMACEUTICALS, INC. (US) 2018-05-01 — — US disclosed
US-20170022221-A1 BENZODIAZEPINE DERIVATIVES AS RSV INHIBITORS ENANTA PHARMACEUTICALS, INC. 2017-01-26 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10865215-B2 Benzodiazepine derivatives as RSV inhibitors GABRA5, GABRA1, GABBR2 MAPK1 2860/4885TP53 4857/4885USP2 4534/4885
US-10881666-B2 Combination pharmaceutical agents as RSV inhibitors SERPINB1, FURIN, HIF1AN MAPK1 2810/4885TP53 3718/4885USP2 4020/4885
US-10570153-B2 Benzodiazepine derivatives as RSV inhibitors GABRA5, GABRA1, GABBR2 MAPK1 2860/4885TP53 4857/4885USP2 4534/4885
US-20220323460-A1 COMBINATION PHARMACEUTICAL AGENTS AS RSV INHIBITORS SERPINB1, FURIN, HIF1AN MAPK1 2810/4885TP53 3718/4885USP2 4020/4885
US-12268694-B2 Combination pharmaceutical agents as RSV inhibitors ACE, ACE2, SPCS3 MAPK1 1820/4885TP53 4005/4885USP2 4529/4885
US-20170022221-A1 BENZODIAZEPINE DERIVATIVES AS RSV INHIBITORS GABRA5, GABRA1, GABBR2 MAPK1 2860/4885TP53 4857/4885USP2 4534/4885
US-20200223867-A1 BENZODIAZEPINE DERIVATIVES AS RSV INHIBITORS GABRA5, GABRA1, GABBR2 MAPK1 2860/4885TP53 4857/4885USP2 4534/4885
US-20190192535-A1 COMBINATION PHARMACEUTICAL AGENTS AS RSV INHIBITORS SERPINB1, FURIN, HIF1AN MAPK1 2810/4885TP53 3718/4885USP2 4020/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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