Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 5/20 | 0.66 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.56 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.56 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.56 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.56 |
| ▸ | CES2 | O00748 | 1/20 | 0.52 |
| ▸ | CES1 | P23141 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2821005 | 0.98 | HDAC1 (0.68) | HDAC1HDAC8SMN1; SMN2KDM4EHPGD | |
| SCHEMBL10971761 | 0.95 | HDAC1 (0.63) | HDAC1HDAC8SMN1; SMN2KDM4EHPGD | |
| SCHEMBL11253655 | 0.88 | SMN1; SMN2 (0.67) | HDAC1HDAC8SMN1; SMN2KDM4EHPGD | |
| SCHEMBL8780100 | 0.85 | HDAC1 (0.68) | HDAC1HDAC8SMN1; SMN2KDM4EHPGD | |
| SCHEMBL13443094 | 0.85 | PTPN1 (0.69) | HDAC1HDAC8SMN1; SMN2KDM4EHPGD | |
| SCHEMBL7387271 | 0.83 | HDAC1 (0.70) | HDAC1HDAC8SMN1; SMN2KDM4EHPGD | |
| SCHEMBL3381304 | 0.83 | HDAC1 (0.70) | HDAC1HDAC8SMN1; SMN2KDM4EHPGD | |
| SCHEMBL8598241 | 0.83 | HDAC1 (0.66) | HDAC1HDAC8SMN1; SMN2KDM4EHPGD | |
| SCHEMBL12065064 | 0.83 | SMN1; SMN2 (0.67) | HDAC1HDAC8SMN1; SMN2KDM4EHPGD | |
| SCHEMBL3379543 | 0.83 | HDAC1 (0.70) | HDAC1HDAC8SMN1; SMN2KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11730705-B2 | Small molecule CMKLR1 antagonists in inflammatory disease | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2023-08-22 | — | — | US | disclosed |
| US-11730705-B2 | Small molecule CMKLR1 antagonists in inflammatory disease | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2023-08-22 | — | — | US | disclosed |
| US-20200345661-A1 | SMALL MOLECULE CMKLR1 ANTAGONISTS IN INFLAMMATORY DISEASE | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2020-11-05 | — | — | US | disclosed |
| US-8841321-B2 | Quinoline derivatives as antibacterial agents | JANSSEN PHARMACEUTICA NV (BE) | 2014-09-23 | — | — | US | disclosed |
| US-8841321-B2 | Quinoline derivatives as antibacterial agents | JANSSEN PHARMACEUTICA NV (BE) | 2014-09-23 | — | — | US | disclosed |
| US-8293732-B2 | Antibacterial quinoline derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2012-10-23 | — | — | US | disclosed |
| US-8293732-B2 | Antibacterial quinoline derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2012-10-23 | — | — | US | disclosed |
| EP-1898914-B1 | QUINOLINE DERIVATIVES AS ANTIBACTERIAL AGENTS | JANSSEN PHARMACEUTICA NV (BE) | 2012-08-15 | — | — | EP | disclosed |
| US-20110166179-A1 | ANTIBACTERIAL QUINOLINE DERIVATIVES | JANSSEN-CILAG (FR) | 2011-07-07 | — | — | US | disclosed |
| US-20110166179-A1 | ANTIBACTERIAL QUINOLINE DERIVATIVES | JANSSEN-CILAG (FR) | 2011-07-07 | — | — | US | disclosed |
| US-20100063026-A1 | ANTIBACTERIAL QUINOLINE DERIVATIVES | VILLAPHARMA RESEARCH S.L. (ES) | 2010-03-11 | — | — | US | disclosed |
| US-20100048585-A1 | QUINOLINE DERIVATIVES AS ANTIBACTERIAL AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2010-02-25 | — | — | US | disclosed |
| US-20100048585-A1 | QUINOLINE DERIVATIVES AS ANTIBACTERIAL AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2010-02-25 | — | — | US | disclosed |
| US-20100029679-A1 | ANTIBACTERIAL QUINOLINE DERIVATIVES | JANSSEN-CILAG (FR) | 2010-02-04 | — | — | US | disclosed |
| US-20100029679-A1 | ANTIBACTERIAL QUINOLINE DERIVATIVES | JANSSEN-CILAG (FR) | 2010-02-04 | — | — | US | disclosed |
| WO-2008068268-A1 | ANTIBACTERIAL QUINOLINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-06-12 | — | — | WO | disclosed |
| WO-2008068266-A1 | ANTIBACTERIAL QUINOLINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-06-12 | — | — | WO | disclosed |
| WO-2008068270-A1 | ANTIBACTERIAL QUINOLINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-06-12 | — | — | WO | disclosed |
| WO-2008068272-A2 | ANTIBACTERIAL QUINOLINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-06-12 | — | — | WO | disclosed |
| WO-2007000435-A1 | QUINOLINE DERIVATIVES AS ANTIBACTERIAL AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-01-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048585-A1 | QUINOLINE DERIVATIVES AS ANTIBACTERIAL AGENTS | NQO2, HRH1, HRH2 | HDAC1 1943/4885HDAC8 3711/4885SMN1; SMN2 4688/4885 |
| US-20200345661-A1 | SMALL MOLECULE CMKLR1 ANTAGONISTS IN INFLAMMATORY DISEASE | CMKLR1, CMKLR2, IL1RN | HDAC1 2763/4885HDAC8 2253/4885SMN1; SMN2 3677/4885 |
| US-11730705-B2 | Small molecule CMKLR1 antagonists in inflammatory disease | CMKLR1, CMKLR2, IL1RN | HDAC1 2763/4885HDAC8 2253/4885SMN1; SMN2 3677/4885 |
| US-20100029679-A1 | ANTIBACTERIAL QUINOLINE DERIVATIVES | NQO2, NDUFB7, NDUFB5 | HDAC1 976/4885HDAC8 3428/4885SMN1; SMN2 2728/4885 |
| US-20110166179-A1 | ANTIBACTERIAL QUINOLINE DERIVATIVES | NQO2, NDUFB5, NDUFB7 | HDAC1 976/4885HDAC8 3361/4885SMN1; SMN2 2755/4885 |
| US-20100063026-A1 | ANTIBACTERIAL QUINOLINE DERIVATIVES | NQO2, NDUFB5, NDUFB7 | HDAC1 1035/4885HDAC8 3440/4885SMN1; SMN2 2488/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.