Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | MMP13 | P45452 | 1/20 | 0.34 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.32 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.32 |
| ▸ | VEGFA | P15692 | 1/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
| ▸ | WNT1 | P04628 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.31 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.31 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17155173 | 0.89 | ALDH1A1 (0.43) | ALDH1A1LMNASMN1; SMN2KDM4EHTT | |
| SCHEMBL17153216 | 0.83 | ACHE (0.37) | ALDH1A1LMNAMMP1MMP9MMP13 | |
| SCHEMBL17152947 | 0.80 | ALDH1A1 (0.52) | ALDH1A1LMNASMN1; SMN2KDM4EHTT | |
| SCHEMBL17152953 | 0.79 | HTR4 (0.33) | ALDH1A1LMNAMMP1MMP9MMP13 | |
| SCHEMBL17152952 | 0.78 | ALDH1A1 (0.45) | ALDH1A1LMNASMN1; SMN2KDM4EHTT | |
| SCHEMBL18412514 | 0.77 | L3MBTL1 (0.43) | ALDH1A1LMNASMN1; SMN2KDM4EHTT | |
| SCHEMBL17152954 | 0.77 | ALDH1A1 (0.43) | ALDH1A1LMNASMN1; SMN2KDM4EHTT | |
| SCHEMBL17152949 | 0.72 | CTSB (0.44) | ALDH1A1LMNASMN1; SMN2KDM4EHTT | |
| SCHEMBL9883952 | 0.71 | ALDH1A1 (0.48) | ALDH1A1LMNASMN1; SMN2KDM4EHTT | |
| SCHEMBL17154922 | 0.70 | ACHE (0.39) | ALDH1A1SMN1; SMN2KDM4EHTTMGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170022201-A1 | MACROCYLIC PYRIDINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2017-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170022201-A1 | MACROCYLIC PYRIDINE DERIVATIVES | VPS26B, VPS4B, VPS28 | ALDH1A1 4381/4885LMNA 4810/4885MMP1 4777/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.