Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC40A1 | Q9NP59 | 4/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | USP1 | O94782 | 1/20 | 0.36 |
| ▸ | PKLR | P30613 | 1/20 | 0.35 |
| ▸ | B3GNT2 | Q9NY97 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18434473 | 0.85 | SLC40A1 (0.68) | SLC40A1HSD17B10HPGDRIPK1TP53 | |
| SCHEMBL18434773 | 0.76 | SLC40A1 (0.59) | SLC40A1RIPK1 | |
| SCHEMBL18434803 | 0.75 | SLC40A1 (0.66) | SLC40A1SMN1; SMN2 | |
| SCHEMBL18434853 | 0.74 | SLC40A1 (0.69) | SLC40A1NPSR1LRRK2 | |
| SCHEMBL18434850 | 0.71 | SLC40A1 (0.70) | SLC40A1HPGDNPSR1 | |
| SCHEMBL487451 | 0.69 | HSP90AA1 (0.78) | HSP90AA1HSP90AB1HSD17B10HPGDNPC1 | |
| SCHEMBL11997178 | 0.68 | SLC40A1 (0.81) | SLC40A1 | |
| SCHEMBL18434857 | 0.68 | SLC40A1 (0.49) | SLC40A1NPC1RAB9ASMN1; SMN2NPSR1 | |
| SCHEMBL18434707 | 0.67 | SLC40A1 (0.59) | SLC40A1 | |
| SCHEMBL18434497 | 0.67 | SLC40A1 (0.65) | SLC40A1HSP90AA1HSD17B10HPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2675526-B1 | NOVEL SULFONAMINOQUINOLINE HEPCIDIN ANTAGONISTS | VIFOR (INTERNATIONAL) AG (CH) | 2017-02-01 | — | — | EP | disclosed |