Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 8/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 8/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 7/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.34 |
| ▸ | GMNN | O75496 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | THPO | P40225 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18448780 | 0.83 | PDE10A (0.35) | CYP11B1CYP11B2THRBTHPORAB9A | |
| SCHEMBL28632021 | 0.83 | MEN1 (0.46) | CYP11B1CYP11B2CYP19A1IDO1MAPT | |
| SCHEMBL18447793 | 0.79 | CYP11B1 (0.56) | CYP11B1CYP11B2CYP19A1IDO1MAPT | |
| SCHEMBL18448786 | 0.76 | ADRA2A (0.44) | IDO1MAPTMAPK1ALDH1A1LMNA | |
| SCHEMBL28642927 | 0.75 | ALDH1A1 (0.40) | CYP11B1CYP11B2CYP19A1MAPTMAPK1 | |
| SCHEMBL28627402 | 0.73 | S1PR4 (0.43) | CYP11B1CYP11B2CYP19A1MAPTMAPK1 | |
| SCHEMBL18449672 | 0.73 | KMT2A (0.47) | CYP11B1CYP11B2CYP19A1IDO1MAPT | |
| SCHEMBL22270628 | 0.73 | LMNA (0.44) | IDO1MAPTMAPK1ALDH1A1MEN1 | |
| SCHEMBL18448782 | 0.72 | CYP19A1 (0.54) | CYP11B1CYP11B2CYP19A1IDO1MAPT | |
| SCHEMBL18447582 | 0.71 | CNR2 (0.47) | CYP19A1MAPTALDH1A1ALOX5KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108026050-B | Novel compounds as ROR gamma modulators | 格兰马克药品股份有限公司 | 2021-04-30 | — | — | CN | disclosed |
| EP-3331863-A1 | NOVEL COMPOUNDS AS ROR GAMMA MODULATORS | Glenmark Pharmaceuticals S.A. (CH) | 2018-06-13 | — | — | EP | disclosed |
| WO-2017021879-A1 | NOVEL COMPOUNDS AS ROR GAMMA MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2017-02-09 | — | — | WO | disclosed |