Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.38 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.35 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | FAAH | O00519 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.30 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21183939 | 0.88 | RAB9A (0.37) | RAB9ALMNAMAPTSMN1; SMN2MEN1 | |
| SCHEMBL14946753 | 0.82 | CACNA1I (0.42) | RAB9ALMNAMAPTSMN1; SMN2KMT2A | |
| SCHEMBL17403570 | 0.76 | RAB9A (0.46) | RAB9ALMNAMAPTSMN1; SMN2MEN1 | |
| SCHEMBL12412536 | 0.73 | HCAR3 (0.54) | RAB9ALMNAMAPTSMN1; SMN2MEN1 | |
| SCHEMBL26199978 | 0.73 | RAB9A (0.43) | RAB9ALMNAMAPTSMN1; SMN2MEN1 | |
| SCHEMBL12293177 | 0.71 | HCAR3 (0.50) | RAB9ALMNAMAPTSMN1; SMN2MEN1 | |
| SCHEMBL24324469 | 0.71 | HIF1A (0.39) | RAB9ALMNAMAPTSMN1; SMN2MEN1 | |
| SCHEMBL13658047 | 0.71 | LMNA (0.41) | RAB9ALMNAMAPTSMN1; SMN2MEN1 | |
| SCHEMBL14946815 | 0.70 | LMNA (0.38) | RAB9ALMNAMAPTSMN1; SMN2MEN1 | |
| SCHEMBL24124013 | 0.70 | RAB9A (0.43) | RAB9ALMNAMAPTSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10766886-B2 | Retinoic acid receptor antagonists as chaperone-mediated autophagy modulators and uses thereof | ALBERT EINSTEIN COLLEGE OF MEDICINE (US) | 2020-09-08 | — | — | US | disclosed |
| US-20190225599-A1 | RETINOIC ACID RECEPTOR ANTAGONISTS AS CHAPERONE-MEDIATED AUTOPHAGY MODULATORS AND USES THEREOF | ALBERT EINSTEIN COLLEGE MEDICINE INC (US) | 2019-07-25 | — | — | US | disclosed |
| US-9890143-B2 | Retinoic acid receptor antagonists as chaperone-mediated authophagy modulators and uses thereof | ALBERT EINSTEIN COLLEGE OF MEDICINE, INC. (US) | 2018-02-13 | — | — | US | disclosed |
| US-20170037039-A1 | RETINOIC ACID RECEPTOR ANTAGONISTS AS CHAPERONE-MEDIATED AUTHOPHAGY MODULATORS AND USES THEREOF | ALBERT EINSTEIN COLLEGE OF MEDICINE, INC. (US) | 2017-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170037039-A1 | RETINOIC ACID RECEPTOR ANTAGONISTS AS CHAPERONE-MEDIATED AUTHOPHAGY MODULATORS AND USES THEREOF | RXRA, RARB, RARA | RAB9A 402/4885LMNA 1121/4885MAPT 1343/4885 |
| US-10766886-B2 | Retinoic acid receptor antagonists as chaperone-mediated autophagy modulators and uses thereof | RARA, RARB, RXRA | RAB9A 285/4885LMNA 1280/4885MAPT 1742/4885 |
| US-20190225599-A1 | RETINOIC ACID RECEPTOR ANTAGONISTS AS CHAPERONE-MEDIATED AUTOPHAGY MODULATORS AND USES THEREOF | RARA, RARB, RXRA | RAB9A 285/4885LMNA 1280/4885MAPT 1742/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.