Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TYR | P14679 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.33 |
| ▸ | APLNR | P35414 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | KIF11 | P52732 | 2/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14946815 | 0.86 | LMNA (0.38) | CACNA1ILMNATYRTSHRTP53 | |
| SCHEMBL855236 | 0.83 | CACNA1I (0.38) | CACNA1ILMNATYRESR1ESR2 | |
| SCHEMBL14653779 | 0.82 | KMT2A (0.44) | LMNATSHRALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL18479367 | 0.82 | RAB9A (0.39) | CACNA1ILMNAESR1ESR2TSHR | |
| SCHEMBL14946749 | 0.80 | CACNA1I (0.38) | CACNA1ILMNATYRESR1ESR2 | |
| SCHEMBL24636032 | 0.80 | CACNA1I (0.36) | CACNA1ILMNATYRESR1ESR2 | |
| SCHEMBL20228078 | 0.80 | CACNA1I (0.36) | CACNA1ILMNATYRESR1ESR2 | |
| SCHEMBL21789532 | 0.80 | CACNA1I (0.36) | CACNA1ILMNATYRTSHRTP53 | |
| SCHEMBL2693246 | 0.80 | PDE2A (0.36) | CACNA1ILMNATYRTSHRSCN10A | |
| SCHEMBL20457815 | 0.80 | CACNA1I (0.36) | CACNA1ILMNATYRESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210387953-A1 | BENZOXAZOLE AND RELATED COMPOUNDS USEFUL AS CHAPERONE-MEDIATED AUTOPHAGY MODULATORS | ALBERT EINSTEIN COLLEGE OF MEDICINE | 2021-12-16 | — | — | US | disclosed |
| US-20210053958-A1 | RETINOIC ACID RECEPTOR ANTAGONISTS AS CHAPERONE-MEDIATED AUTOPHAGY MODULATORS AND USES THEREOF | COM AFFILIATION, INC. | 2021-02-25 | — | — | US | disclosed |
| US-9890143-B2 | Retinoic acid receptor antagonists as chaperone-mediated authophagy modulators and uses thereof | ALBERT EINSTEIN COLLEGE OF MEDICINE, INC. (US) | 2018-02-13 | — | — | US | disclosed |
| US-9732083-B2 | Tricyclic gyrase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-08-15 | — | — | US | disclosed |
| US-20170037039-A1 | RETINOIC ACID RECEPTOR ANTAGONISTS AS CHAPERONE-MEDIATED AUTHOPHAGY MODULATORS AND USES THEREOF | ALBERT EINSTEIN COLLEGE OF MEDICINE, INC. (US) | 2017-02-09 | — | — | US | disclosed |
| US-20170037039-A1 | RETINOIC ACID RECEPTOR ANTAGONISTS AS CHAPERONE-MEDIATED AUTHOPHAGY MODULATORS AND USES THEREOF | ALBERT EINSTEIN COLLEGE OF MEDICINE, INC. (US) | 2017-02-09 | — | — | US | disclosed |
| US-9512092-B2 | Retinoic acid receptor antagonists as chaperone-mediated autophagy modulators and uses thereof | ALBERT EINSTEIN COLLEGE OF MEDICINE, INC. (US) | 2016-12-06 | — | — | US | disclosed |
| US-20150166492-A1 | RETINOIC ACID RECEPTOR ANTAGONISTS AS CHAPERONE-MEDIATED AUTOPHAGY MODULATORS AND USES THEREOF | ALBERT EINSTEIN COLLEGE OF MEDICINE | 2015-06-18 | — | — | US | disclosed |
| US-8507481-B2 | Benzoxazine oxazolidinone compounds, preparation methods and uses thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2013-08-13 | — | — | US | disclosed |
| US-20130123249-A1 | NOVEL BENZOXAZINE OXAZOLIDINONE COMPOUNDS, PREPARATION METHODS AND USES THEREOF | NANJING CHANGAO PHARMACEUTICAL SCIENCE & TECHNOLOGY CO., LIMITED (CN) | 2013-05-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170037039-A1 | RETINOIC ACID RECEPTOR ANTAGONISTS AS CHAPERONE-MEDIATED AUTHOPHAGY MODULATORS AND USES THEREOF | RXRA, RARB, RARA | CACNA1I 4750/4885LMNA 1121/4885TYR 3039/4885 |
| US-20130123249-A1 | NOVEL BENZOXAZINE OXAZOLIDINONE COMPOUNDS, PREPARATION METHODS AND USES THEREOF | XDH, OXA1L, CYP3A5 | CACNA1I 757/4885LMNA 2379/4885TYR 1484/4885 |
| US-20150166492-A1 | RETINOIC ACID RECEPTOR ANTAGONISTS AS CHAPERONE-MEDIATED AUTOPHAGY MODULATORS AND USES THEREOF | RARA, RARB, RXRA | CACNA1I 4770/4885LMNA 1280/4885TYR 2905/4885 |
| US-20210053958-A1 | RETINOIC ACID RECEPTOR ANTAGONISTS AS CHAPERONE-MEDIATED AUTOPHAGY MODULATORS AND USES THEREOF | RARA, RARB, RXRA | CACNA1I 4770/4885LMNA 1280/4885TYR 2905/4885 |
| US-20210387953-A1 | BENZOXAZOLE AND RELATED COMPOUNDS USEFUL AS CHAPERONE-MEDIATED AUTOPHAGY MODULATORS | CLPX, SQSTM1, ATG7 | CACNA1I 2465/4885LMNA 2356/4885TYR 1313/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.