Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 3/20 | 0.53 |
| ▸ | EGFR | P00533 | 13/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 2/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.43 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18447775 | 0.79 | EGFR (0.49) | EGFRLMNAHPGDSMN1; SMN2AURKA | |
| SCHEMBL9403796 | 0.78 | EGFR (0.55) | CRHR1EGFRAURKARPS6KB1 | |
| SCHEMBL18447771 | 0.73 | EGFR (0.47) | EGFRAURKARPS6KB1 | |
| SCHEMBL430689 | 0.71 | MAPKAPK2 (0.54) | EGFRLMNARPS6KB1MAPKAPK2 | |
| SCHEMBL27783713 | 0.71 | MAPKAPK2 (0.54) | EGFRLMNARPS6KB1MAPKAPK2 | |
| SCHEMBL20095129 | 0.71 | MAPKAPK2 (0.54) | EGFRLMNARPS6KB1MAPKAPK2 | |
| SCHEMBL6754929 | 0.70 | KDM4E (0.69) | EGFRSMN1; SMN2MAPKAPK2 | |
| SCHEMBL6420641 | 0.70 | KDM4E (0.69) | EGFRSMN1; SMN2MAPKAPK2 | |
| SCHEMBL30610263 | 0.70 | TRPM8 (0.39) | LMNASMN1; SMN2 | |
| SCHEMBL5207074 | 0.70 | ATP1A1 (0.49) | CRHR1EGFRLMNARPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017021879-A1 | NOVEL COMPOUNDS AS ROR GAMMA MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2017-02-09 | — | — | WO | disclosed |